REVIEW | doi:10.20944/preprints202309.1320.v1
Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: bladder; breast cancer; hot flashes; hyperhidrosis; obstructive sleep apnea; oxybutynin; prostate cancer
Online: 20 September 2023 (09:49:35 CEST)
Since decades, oxybutynin hydrochloride is prescribed to improve bladder control in cases of incontinence and excessive urination frequency. This review summarizes synthetic methods enabling preparation of the racemic drug and, in a detailed manner, preparation of (S)-2-cyclohexyl-2-hydroxy-2-phenylacetic acid, a key intermediate in the synthesis of (S)-oxybutynin. Mode of action and metabolism are briefly commented in order to explain the main adverse effects associated with its use and to justify the evolution observed in the diverse commercial formulations. Repositioning opportunities are discussed in terms of clinical trials for the management of hyperhidrosis, hot flashes, and obstructive sleep apnea.