The Family Management Measure (FaMM) is a theory-based instrument for assessing how families manage childhood chronic conditions; however, evidence supporting its cross-cultural structural validity remains limited, and no validated Thai version is available. This methodological study translated, cross-culturally adapted, and psychometrically evaluated the Thai FaMM among 350 primary family caregivers of children with chronic conditions. Translation followed the International Society for Pharmacoeconomics and Outcomes Research Task Force guidelines, and psychometric evaluation was guided by the Consensus-based Standards for the Selection of Health Measurement Instruments framework. Structural validity was examined using exploratory and confirmatory factor analyses with independent split-half samples, followed by second-order confirmatory factor analysis where appropriate. The Child’s Daily Life scale retained its original unidimensional structure, whereas Condition Management Ability, Family Life Difficulty, View of Condition Impact, and Parental (Caregiver) Mutuality were more accurately represented by multidimensional hierarchical measurement models. Five of the six scales demonstrated satisfactory structural validity, internal consistency, item discrimination, and excellent test–retest and interobserver reliability. In contrast, the Condition Management Effort scale demonstrated inadequate structural validity and internal consistency. The Thai FaMM is a culturally appropriate and psychometrically robust instrument that extends cross-cultural measurement of the Family Management Style Framework by demonstrating that several family management constructs are better represented as multidimensional hierarchical constructs within the Thai sociocultural context.