(1) Background: The mink farming industry was established in Ireland in the 1950s and despite a significant decline in farm numbers over subsequent decades, it remained economically important due to the employment it provided in disadvantaged rural areas. However, growing animal welfare concerns, supported by scientific reviews and advocacy from animal welfare groups and veterinary professionals, increased pressure for legislative reform. This article examines the development of the Irish mink farming industry, the factors leading to its prohibition, and Ireland's position within broader European trends concerning fur farming. (2) Methods: The article adopts a historical and legal approach, analyzing industry data, government policy, animal welfare advocacy, scientific reviews, and legislative developments from the 1950s to the enactment of the Animal Health and Welfare and Forestry (Miscellaneous Provisions) Act 2022. (3) Results: The analysis demonstrates that mink farming declined from approximately forty producers in 1960 to three farms by 2022. Concerns about the welfare of farmed mink gained prominence, particularly following Veterinary Ireland’s call for an end to fur farming and the publication of scientific reviews challenging fur production practices. These developments informed government policy and led to legislation prohibiting the breeding and keeping of animals for fur production. (4) Conclusions: Ireland’s prohibi-tion of mink farming reflects a policy shift towards prioritizing animal welfare over a declining industry. Scientific evidence, ethical concerns, and sustained advocacy were central to this legislative change, positioning Ireland ahead of broader European Union developments in the regulation of fur farming.