Locally Advanced Pancreatic Adenocarcinoma Treated With Neoadjuvant Systemic Therapy, Phosphorus-32 Brachytherapy, And Surgery: From Diagnosis To Histopathology

Introduction: Locally advanced pancreatic adenocarcinoma remains a major therapeutic challenge, with limited curative options. In recent years, several multimodal approaches combining systemic therapies with innovative locoregional treatments such as endoscopic brachytherapy with Phosphorus-32 have shown promising results. Case Presentation: We report the case of a patient diagnosed with locally advanced adenocarcinoma of the pancreatic head who underwent neoadjuvant chemotherapy followed by Phosphorus-32 brachytherapy and subsequent surgical resection. Conclusions: The multimodal approach resulted in a near-complete response on histopathological examination, good local disease control, and acceptable tolerability, thereby suggesting a potential role for brachytherapy in selected patients with locally advanced pancreatic tumors.