Background/Objectives: This study evaluates the adaptation of a novel filling material (Odne®Fill, Switzerland) to the walls of the shaped root canal using micro-computed tomography. Methods: Fourteen extracted human molars (6 maxillary and 8 mandibular), comprising a total of 32 root canals, were included. After canal preparation, all canals were filled with Odne®Fill according to the manufacturer’s instructions. Periapical radiographs and micro-computed tomography were used to assess the extent of canal wall coverage by the filling material. Surface coverage was quantified by image segmentation and statistically analyzed. Results: The percentage of canal wall coverage ranged from 93.31% to 99.98%. The mean coverage rate was 97.63% (SD 1.70%) and the median was 98.23%, indicating a high degree of adaptation of the filling material to the ex vivo prepared canal walls. Conclusions: Under the conditions of this ex vivo study Odne®Fill demonstrated high canal wall adaptation values. These findings should be interpreted with caution and further com-parative and long-term studies are required before clinical relevance can be established.