A descent sequence is a word π = π1π2 · · · πn of nonnegative integers satisfying π1 = 0 and πi ≤ 1 + des(π1π2 · · · πi-1) for i = 2, 3, . . . , n, where des(π1π2 · · · πm) denotes the number of indices j such that πj > πj+1. In this work, we study descent sequences subject to the additional restriction of avoiding a given pattern of length four. We analyze seven distinct avoidance classes and provide enumerative results for each of them. Our approach is based on the construction of generating trees with one or two labels, from which we derive succession rules and corresponding systems of recurrence relations. These recurrences are then used to compute explicit generating functions for the number of descent sequences of length n avoiding either 0001, 0010, 0011, 0012, 0021, 0110, 0112, 0123, or 0132.