This paper presents the results of research aimed at identifying deep-seated natural sealed reservoirs for the isolation of chemically active gases, including CO₂. A comprehensive analysis of geological, geophysical, and hydrogeological data was conducted to identify potential structures within the aquifers of Almaty and the Almaty region (Southern Kazakhstan) capable of capturing and storing carbon dioxide under geographically favorable and economically viable conditions. The study utilizes seismic survey results and drilling data from the eastern part of the Ili Basin, demonstrating the efficacy of seismic exploration in identifying stratigraphic horizons and their structural-tectonic settings. Based on an integrated analysis of available geo-physic information, the lithological and stratigraphic characteristics of the sedimentary cover in the Ili Basin are substantiated. Key caprock sequences and reservoir units for potential storage sites are identified, and recommendations for further geological exploration are provided. Five reflecting horizons were identified within the geological section of the troughs. It was established that the Miocene-Paleogene and Jurassic horizons contain sandstone reservoirs with a thickness exceeding 10 m and enhanced filtration properties. Clay complexes are prevalent in the Upper Jurassic deposits, which can serve as a caprock for these reservoir rocks. Furthermore, the Upper Cretaceous clay sequence may act as a fluid seal for the Neogene-Paleogene sandy horizons. Such conditions meet the requirements for sealed reservoirs for the isolation of chemically active gases, including CO₂. According to hydrogeological studies, seven aquifer complexes are distinguished: Permian, Triassic, Jurassic, Cretaceous, Paleogene, Neogene and Quaternary. The novelty and practical significance of this research lie in obtaining new information on the geological structure of deep horizons in poorly studied areas of the Ili Basin and establishing favorable geological factors for identifying potential sites suitable for carbon dioxide sequestration.