Submitted:
05 May 2026
Posted:
06 May 2026
You are already at the latest version
Abstract
Disruption of sleep and circadian rhythms is a lesser-known, but pervasive symptom of Parkinson’s disease. It impacts patients’ health, well-being, and may exacerbate disease progression. This review summarises how currently established treatments impact Parkinsonian sleep and circadian rhythms, and highlights experimental treatments (chronotherapies) that specifically target these symptoms. We argue deep brain stimulation technology may have the potential to deliver particularly effective chronotherapy, and we explore several potential therapeutic strategies.
Keywords:
Parkinson’s disease
; PD
; circadian rhythms
; deep brain stimulation
; DBS
; chronotherapy
; neuromodulation
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
