Optimising production layouts in manufacturing plants is a time-consuming and often manual process that typically only considers individual performance indicators. This paper presents an end-to-end pipeline that uses variational autoencoders to generate and optimise layouts. The method simultaneously considers multiple KPIs such as throughput time, energy consumption, space utilisation, machine density and material flow complexity. Different scenarios like standard, bottleneck, energy focus are supported. Results show that the proposed method generates valid layouts that outperform existing layouts in terms of efficiency, energy consumption and material flow. The pipeline enables fast, reproducible layout generation and can be directly integrated into production control systems to achieve measurable technical improvements.