Submitted:
18 March 2026
Posted:
19 March 2026
You are already at the latest version
Abstract
Keywords:
1. Introduction
1.1. Relevance and Problem Statement
1.2. Central Research Question
1.3. Objective
2. Theory
2.1. Anatomical and Biomechanical Foundations
2.2. Pathophysiology of Lumbar Radiculopathy
2.3. Psychosocial Influencing Factors
3. Methodology
3.1. Literature Search
- PubMed/MEDLINE,
- Cochrane Library and
- PEDro
| P | Patients with lumbar radiculopathy |
| I | Conservative physiotherapeutic treatment |
| C | Surgical interventions |
| O | Pain reduction and functional improvement |
| P | Lumbar radiculopathy, Sciatica, Herniated disc, Low back pain |
| I | Conservative, Physiotherapy, Exercise therapy |
| C | Operative, Surgical, Discectomy, Microdiscectomy, Spinal fusion |
| O | Pain reduction, Functional improvement, Disability evaluation, Return to work, Patient satisfaction |
3.2. Criteria for Study Selection
3.3. Analysis and Synthesis of Results
| References | Category | IDs |
| 5 | Description of conservative approaches and their effects | [20], [21], [22], [29], [32] |
| 3 | Description of surgical approaches and their effects | [25], [26], [30] |
| 6 | Comparative or combined conservative and surgical care | [3], [4], [7], [27], [28], [31] |
| 3 | Psychosocial context factors | [6], [15], [24] |
| 11 | Other relevant areas (pharmacological therapy, pathophysiology, etc.) | [1], [2], [5], [8], [9], [10], [11], [12], [13], [14], [23] |
3.4. Use of AI tools
4. Results
4.1. Conservative Therapy
4.2. Surgical Therapy
4.3. Comparison of Treatment Outcomes
5. Discussion
5.1. Answer to the Research Question
5.2. Implications for Clinical Practice
- Comprehensive diagnostics including standardized psychosocial screening tests with special attention to red flags and differential diagnoses
- Education about therapy options and neurophysiological pain mechanisms, including long-term consequences
- Decision-making processes prioritizing conservative treatment options and patient preferences
- Development of long-term therapy strategies
6. Conclusion
Funding
Conflicts of Interest
Appendix A
| 1. Justification of the article’s importance for the readership | Score | |
|
- The importance is not justified - The importance is alluded to, but not explicitly justified - The importance is explicitly justified |
0 1 2 |
2 |
| 2. Statement of concrete aims or formulation of questions | ||
|
- No aims or questions are formulated - Aims are formulated generally but not concretely or in terms of clear questions - One or more concrete aims or questions are formulated |
0 1 2 |
2 |
| 3. Description of the literature search | ||
|
- The search strategy is not presented - The literature search is described briefly - The literature search is described in detail, including search terms and inclusion criteria |
0 1 2 |
1 |
| 4. Referencing | ||
|
- Key statements are not supported by references - The referencing of key statements is inconsistent - Key statements are supported by references |
0 1 2 |
2 |
| 5. Scientific reasoning | ||
|
- The article’s point is not based on appropriate arguments - Appropriate evidence is introduced selectively - Appropriate evidence is generally present |
0 1 2 |
2 |
| 6. Appropriate presentation of data | ||
|
- Data are presented inadequately - Data are often not presented in the most appropriate way - Relevant outcome data are generally presented appropriately |
0 1 2 |
1 |
| Sumscore | 12 | 10 |
References
- Bittschi, B; Mayrhuber, C. Fehlzeitenreport 2024. Krankheits- und unfallbedingte Fehlzeiten in Österreich: Österreichisches Institut für Wirtschaftsforschung, 2024. Available online: https://www.sozialversicherung.at/cdscontent/load?contentid=10008.789000&version=1719902096.
- Koch-Institut, Robert. Muskulo skelettale Erkrankung. 2023. Available online: https://www.rki.de/DE/Themen/Nichtuebertragbare-Krankheiten/Koerperliche-Gesundheit/Muskuloskelettale-Erkrankungen/muskuloskelettale-erkrankungen-node.html.
- Greitemann, B; Schmidt, R. S2k-Leitlinie: Konservative, operative und rehabilitative Versorgung bei Bandscheibenvorfällen mit radikulärer Symptomatik: Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). 2021. Available online: https://register.awmf.org/assets/guidelines/033-048l_S2k_Konservative-operative_rehabilitative-Versorgung-Bandscheibenvorfall-radikulae_2021-06_01.pdf.
- Glocker, F. S2k-Leitlinie: Lumbale Radikulopathie: Leitlinien für Diagnostik und Therapie in der Neurologie: Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). 2018. Available online: https://dnvp9c1uo2095.cloudfront.net/cms-content/030058_LL_Lumbale_Radikulopathie_2018_archiviert_1726228804828.pdf.
- Hincapié, C; Kroismayr, D; Hofstetter, L; et al. Incidence of and risk factors for lumbar disc herniation with radiculopathy in adults: a systematic review. European spine journal 2025, 34(1), 263–94. [Google Scholar] [CrossRef] [PubMed]
- Eich, W; Diezemann-Prößdorf, A; Hasenbring, M; et al. Psychosoziale Faktoren bei Schmerz und Schmerzbehandlung: Eine Positionsbestimmung. Schmerz 2023, 37(3), 159–67. [Google Scholar] [CrossRef] [PubMed]
- Hammed, A; Al-Qiami, A; Alsalhi, H; et al. Surgical vs. Conservative Management of Chronic Sciatica (3 Months) Due to Lumbar Disc Herniation: Systematic Review and Meta-Analysis. Cureus 2024, 16(5), e59617. [Google Scholar] [CrossRef] [PubMed]
- Farshad, M; Wanivenhaus, F; Spirig, J; Betz, M; Unterfrauner, I. Wirbelsäule: Anatomie. In Lehrbuch Orthopädie: Was man wissen muss, 2. Auflage; Farshad, M, Ed.; Springer: Berlin, Heidelberg, 2023; pp. 7–42. [Google Scholar]
- Liu, C; Xue, J; Liu, J; et al. Is there a correlation between upper lumbar disc herniation and multifidus muscle degeneration? A retrospective study of MRI morphology. BMC Musculoskelet Disord 2021, 22(1), 92. [Google Scholar] [CrossRef] [PubMed]
- Welke, B; Daentzer, D; Neidlinger-Wilke, C; Liebsch, C. Biomechanik der Bandscheibe: Bedeutung degenerativer Veränderungen. Orthopädie 2024, 53(12), 912–7. [Google Scholar] [CrossRef] [PubMed]
- Dalley, AF; Agur, AMR; Moore, KL. Moore's clinically oriented anatomy, 9th ed.; Wolters Kluwer: Philadelphia, 2024. [Google Scholar]
- Schmid, A; Fundaun, J; Tampin, B. Nervenkompressionssyndrome – eine aktuelle Betrachtung von Pathophysiologie, klinischer Untersuchung und Management: Deutsche Fassung. Schmerz 2021, 35(6), 419–33. [Google Scholar] [CrossRef] [PubMed]
- Cooley, J; Jensen, T; Kjaer, P; Jacques, A; Theroux, J; Hebert, J. Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain. Sci Rep 2022, 12(1), 14676. [Google Scholar] [CrossRef] [PubMed]
- Naghdi, N; Mohseni-Bandpei, M; Taghipour, M; Rahmani, N; Gonil, F. Lumbar Multifidus Muscle Morphology Changes in Patient with Different Degrees of Lumbar Disc Herniation: An Ultrasonographic Study. Medicina (Kaunas) 2021, 57(7), 688. [Google Scholar] [CrossRef] [PubMed]
- Javeed, S; Benedict, B; Yakdan, S; et al. Implications of Preoperative Depression for Lumbar Spine Surgery Outcomes: A Systematic Review and Meta-Analysis. JAMA Netw Open 2024, 7(1), e2348565. [Google Scholar] [CrossRef] [PubMed]
- Wissenschaftliches Arbeiten und Schreiben: Verstehen, Anwenden, Nutzen für die Praxis, 2. Auflage; Ritschl, V, Weigl, R, Stamm, T, Eds.; Springer: Berlin, Heidelberg, 2023. [Google Scholar]
- Blümle, A; Sow, D; Nothacker, M; et al. Manual Systematische Recherche für Evidenzsynthesen und Leitlinien: Cochrane Deutschland Stiftung, Institut für Evidenz in der Medizin, Institut für Medizinische Biometrie und Statistik, Freiburg, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften - Institut für Medizinisches Wissensmanagement, Ärztliches Zentrum für Qualität in der Medizin. 2020. Available online: https://www.cochrane.de/de/literaturrecherche.
- Cashin, A; McAuley, J. Clinimetrics: Physiotherapy Evidence Database (PEDro) Scale. J Physiother 2020, 66(1), 59. [Google Scholar] [CrossRef] [PubMed]
- Baethge, C; Goldbeck-Wood, S; Mertens, S. SANRA-a scale for the quality assessment of narrative review articles. Res Integr Peer Rev 2019, 4, 5. [Google Scholar] [CrossRef] [PubMed]
- Dove, L; Jones, G; Kelsey, L; Cairns, M; Schmid, A. How effective are physiotherapy interventions in treating people with sciatica? A systematic review and meta-analysis. European spine journal 2023, 32(2), 517–33. [Google Scholar] [CrossRef] [PubMed]
- Jäntsch-Rieckert, M; Rommel, O; Kästner, V; Maercklin-Rommel, L; Jäger, G. Konservative Kombinationstherapie beim lumbalen Bandscheibenvorfall mit Nervenwurzelreizsyndrom mit mechanischer Physiotherapie (McKenzie), Gabapentin und transforaminalen epiduralen Infiltrationen. Schmerz 2024. [Google Scholar] [CrossRef] [PubMed]
- Taxer, B. Die Rolle der Physiotherapie bei neuropathischen Schmerzen. Schmerz Nachrichten 2024, 24(2), 84–7. [Google Scholar] [CrossRef]
- Laube, W. Neuroanatomie und Neurophysiologie der Motorik: Wechselwirkungen des sensomotorischen Systems. In Therapeutisches Arbeiten in der Neuroorthopädie: Multiprofessionelle Teamarbeit und transdisziplinäres Denken; Strobl, W, Abel, C, Pitz, E, Schikora, N, Eds.; Springer: Berlin, Heidelberg, 2021; pp. 10–5. [Google Scholar]
- Malfliet, A; Kregel, J; Coppieters, I; et al. Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial. JAMA Neurol 2018, 75(7), 808–17. [Google Scholar] [CrossRef] [PubMed]
- Rushton, A; Heneghan, N; Heymans, M; Staal, J; Goodwin, P. Clinical course of pain and disability following primary lumbar discectomy: systematic review and meta-analysis. European spine journal 2020, 29(7), 1660–70. [Google Scholar] [CrossRef] [PubMed]
- Hermansen, A; Hedlund, R; Zsigmond, P; Peolsson, A. A more than 20-year follow-up of pain and disability after anterior cervical decompression and fusion surgery for degenerative disc disease and comparisons between two surgical techniques. BMC Musculoskelet Disord 2023, 24(1), 406. [Google Scholar] [CrossRef] [PubMed]
- Liu, C; Ferreira, G; Abdel, S.; et al. Surgical versus non-surgical treatment for sciatica: systematic review and meta-analysis of randomised controlled trials. BMJ 2023, 381, e070730. [Google Scholar] [CrossRef] [PubMed]
- Rickers, K; Pedersen, P; Tvedebrink, T; Eiskjær, S. Comparison of interventions for lumbar disc herniation: a systematic review with network meta-analysis. The spine journal 2021, 21(10), 1750–62. [Google Scholar] [CrossRef] [PubMed]
- Manchikanti, L; Knezevic, E; Knezevic, N; et al. Epidural Injections for Lumbar Radiculopathy or Sciatica: A Comparative Systematic Review and Meta-Analysis of Cochrane Review. Pain Physician 2021, 24(5), 539–554. [Google Scholar] [PubMed]
- Clark, R; Weber, RP; Kahwati, L. Surgical Management of Lumbar Radiculopathy: a Systematic Review. J Gen Intern Med 2020, 35(3), 855–64. [Google Scholar] [CrossRef] [PubMed]
- Özden, F; Koçyiğit, GZ. The effect of early rehabilitation after lumbar spine surgery: a systematic review and meta-analysis. Egypt J Neurosurg 2024, 39(1), 8. [Google Scholar] [CrossRef]
- Kim, C; Choi, Y; Chung, C; et al. Nonsurgical treatment outcomes for surgical candidates with lumbar disc herniation: a comprehensive cohort study. Sci Rep 2021, 11(1), 3931. [Google Scholar] [CrossRef] [PubMed]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2026 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.