Serum Myeloperoxidase, Xanthine Oxidase, and Oxidized Low-Density Lipoprotein As Determinants of Blood Pressure Among Abdominally Obese Adult Subjects

Background: Obesity is a risk factor for increased blood pressure, in which the relation-ship is mediated by the action of various pro-inflammatory mediators such as myelop-eroxidase (MPO), xanthine oxidase (XO), and oxidized low-density lipoprotein (Ox-LDL). The objective of this research is to evaluate the contribution serum MPO, xanthine oxidase XO, and Ox-LDL as determinants of blood pressure in adults with abdominal obesity. Methods: A cross-sectional study was conducted involving 86 adults with abdominal obesity. Waist circumference (WC), fasting serum glucose (FSG), MPO, XO, and serum Ox-LDL were measured. The contributions of these parameters to systolic blood pressure (SBP) and diastolic blood pressure (DBP) were then assessed. Results: Multivariate analy-sis showed that the determinants of SBP were WC, FSG, MPO, and XO (Beta = 0.418, 0.328, 0.282, 0.248 respectively, all p< 0.05; adjusted R2 = 41.5%), while the determinants of DBP were FSG, WC, and MPO (Beta = 0.310, 0.284, 0.274, respectively, all p< 0.05; adjusted R2 = 24.8%). Conclusions: MPO has a role as a determining factor for SBP and DBP, XO has a role as a determining factor for SBP, while Ox-LDL does not have a significant role in blood pressure.