The STEAM-CT approach integrates Science, Technology, Engineering, Arts, and Mathematics with Computational Thinking (CT) to help students learn how to think, design, and solve problems. It gives students hands-on, interdisciplinary experiences where they apply logic and creativity through real-world applications. The purpose of this study is to foster the development of computational thinking among Deaf students by embedding Artificial Intelligence (AI) learning within a STEAM-CT approach. This learning program consisted of three main phases: (1) exploring AI processes and tools, (2) constructing an AI system, and (3) designing AI-driven innovations. Thirty-six Deaf students from seven Deaf schools participated in this program, which aims to enhance their CT abilities and cultivate their capacity to create AI-based solutions. Students’ progress was measured using a CT framework encompassing knowledge of concepts, applied practices and perspectives. Assessments included multiple-choice tests for CT concepts, task-based rubrics for CT practices, and interviews for CT perspectives. The results showed that Deaf students gained a better understanding of CT concepts, demonstrated advanced CT practices, and exhibited strong CT perspectives. These findings suggest that AI learning through a STEAM-CT approach can effectively promote Deaf students’ computational thinking abilities.