The Framework of Host Innate and Adaptive Immunological Pathways

The whole framework of host innate and adaptive immunological pathways is proposed. In the innate immunity, γδ T cells can be categorized into several groups. Clonal anergy and tolerance pathway is related to Vγ2 chain γδ T cells. Host innate immunological pathway against viruses is related to Vγ8 chain γδ T cells. Host innate immunological pathway against intracellular micro-organisms is related to Vγ9 chain γδ T cells. Host innate immunological pathway against extracellular micro-organisms is related to Vγ4 chain γδ T cells. Host innate immunological pathway against helminths is related to Vγ3 chain γδ T cells. Host innate immunological pathway against insects is related to Vγ5 chain γδ T cells. In the adaptive immunity, there are five eradicable immune reactions and four tolerable immune reactions. In the tolerable immune reactions, TH3 is related to interleukin-35 producing CD4 T cells, and TH4 is related to interleukin-32 producing CD4 T cells.