Submitted:
19 January 2026
Posted:
21 January 2026
You are already at the latest version
Abstract
Keywords:
Introduction: From Cartography to Interrogation
Ontological Foundation: Reality as a Latent Field
Methodology: The Mechanics of Provocative Measurement
- Construction of Divergent Models: Two or more precise, quantitative predictive models (P1(π), P2(π)) are formulated. P1 represents the null expectation based on the standard model (S), while P2 incorporates a hypothesized latent structure (H) as a physical constraint. Their predictions for a specific observable must diverge beyond a defined confidence interval.
- Application of the Ze Probe: The probe π is derived as the material instantiation of the predictive question. It is a minimal, precisely calibrated perturbation (e.g., a resonant electromagnetic field, a sub-critical metabolic challenge) engineered to be maximally sensitive to the differential imposed by H (Engel et al., 2007; Soto, 2003).
- Detection of Forced Localization: The system's response is monitored for an outcome that cannot be explained as noise within P1 and aligns with the violation pattern characteristic of the conflict between P1 and P2.
Ze Systems as Entropy Engines: The Thermodynamics of Knowledge
- Generating Entropy: This active sculpting expends energy to alter states, increasing disorder as the model attempts to impose its order. This aligns with the Landauer principle, which establishes that erasing a bit of information (collapsing possibilities) dissipates a minimum of kBTln(2) energy as heat, increasing environmental entropy (Landauer, 1961).
- Truth from Residual Entropy: If no deep latent structure exists, the cheating model succeeds, reshaping reality into a trivial reflection of itself. However, if a true latent structure (L) exists—a homeostatic set-point, a topological constraint—it resists. The cheating actions meet "friction," producing a persistent, structured residual error (ϵL) that M cannot eliminate. This residual is the signal; truth is localized in the pattern of this informative failure (Tkemaladze, 2026).
Implications and Case Studies
- Precision Oncology: A targeted kinase inhibitor is a materialized cheating model (M). Its initial success in forcing tumor remission is a successful "cheat." The emergence of drug-resistant subclones is not merely a clinical failure but the generation of ϵL, revealing the tumor's latent heterogeneity and guiding next-generation therapy (Druker, 2008).
- Neuroscience: The placebo response is an endogenous cheating loop. Individual variability in this response, linked to genetic polymorphisms, constitutes the detectable ϵL, revealing latent biological constraints on the mind-body predictive system (Hall, Loscalzo, & Kaptchuk, 2015).
- Cognitive Science: Cognitive-Behavioral Therapy (CBT) can be viewed as a collaborative Ze system, where behavioral experiments act as cheating levers against maladaptive predictive models. The core schemas that resist change are the latent structures (L) localized by their persistent residual (ϵL) (Beck, 2011).
- Machine Learning: Overfitting is a degenerate form of a greedy model's success, where the model "cheats" perfectly on training data. Its failure to generalize is the catastrophic emergence of ϵL, revealing that its "truth" was an artifact of its sculpting power over a limited domain (Mehrabi et al., 2021).
Ethical Reckoning: The Cost of Co-Creation
- Energetic Price: The thermodynamic cost of forced localization (Landauer, 1961).
- Ontological Price: The annihilation of unactualized potential states, a permanent pruning of possible futures.
- Historical Price: The irreversible alteration of the system onto a new trajectory.
Conclusion
Ethics approval and consent to participate
Consent for publication
Availability of data and materials
Competing interests
Funding
Acknowledgments
Authors' contributions
Declaration of generative AI and AI-assisted technologies in the writing process
References
- Aharonov, Y.; Albert, D. Z.; Vaidman, L. How the result of a measurement of a component of the spin of a spin-1/2 particle can turn out to be 100. Physical Review Letters 1988, 60(14), 1351–1354. [Google Scholar] [CrossRef] [PubMed]
- Barad, K. Meeting the universe halfway: Quantum physics and the entanglement of matter and meaning; Duke University Press, 2007. [Google Scholar]
- Beck, J. S. Cognitive behavior therapy: Basics and beyond, 2nd ed.; Guilford Press, 2011. [Google Scholar]
- Druker, B. J. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008, 112(13), 4808–4817. [Google Scholar] [CrossRef] [PubMed]
- Engel, G. S.; Calhoun, T. R.; Read, E. L.; Ahn, T.-K.; Mančal, T.; Cheng, Y.-C.; Blankenship, R.E.; Fleming, G. R. Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems. Nature 2007, 446(7137), 782–786. [Google Scholar] [CrossRef] [PubMed]
- Grangier, P.; Roger, G.; Aspect, A. Experimental evidence for a photon anticorrelation effect on a beam splitter: A new light on single-photon interferences. Europhysics Letters 1986, 1(4), 173–179. [Google Scholar] [CrossRef]
- Hall, K. T.; Loscalzo, J.; Kaptchuk, T. J. Genetics and the placebo effect: the placebo. Trends in Molecular Medicine 2015, 21(5), 285–294. [Google Scholar] [CrossRef]
- Hanahan, D.; Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 2011, 144(5), 646–674. [Google Scholar] [CrossRef] [PubMed]
- Heisenberg, W. Über den anschaulichen Inhalt der quantentheoretischen Kinematik und Mechanik. Zeitschrift für Physik 1927, 43(3-4), 172–198. [Google Scholar] [CrossRef]
- Josselyn, S. A.; Tonegawa, S. Memory engrams: Recalling the past and imagining the future. Science 2020, 367(6473), eaaw4325. [Google Scholar] [CrossRef] [PubMed]
- Landauer, R. Irreversibility and heat generation in the computing process. IBM Journal of Research and Development 1961, 5(3), 183–191. [Google Scholar] [CrossRef]
- Mehrabi, N.; Morstatter, F.; Saxena, N.; Lerman, K.; Galstyan, A. A survey on bias and fairness in machine learning. ACM Computing Surveys 2021, 54(6), 1–35. [Google Scholar] [CrossRef]
- Schrödinger, E. An undulatory theory of the mechanics of atoms and molecules. Physical Review 1926, 28(6), 1049–1070. [Google Scholar] [CrossRef]
- Soto, C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nature Reviews Neuroscience 2003, 4(1), 49–60. [Google Scholar] [CrossRef] [PubMed]
- Tekmaladze, J. Ze System Manifesto. Longevity Horizon 2026, 2(1). [Google Scholar] [CrossRef]
- Zurek, W. H. Decoherence, einselection, and the quantum origins of the classical. Reviews of Modern Physics 2003, 75(3), 715–775. [Google Scholar] [CrossRef]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
