Submitted:
16 January 2026
Posted:
19 January 2026
You are already at the latest version
Abstract
Keywords:
1. Introduction
2. Materials and Methods
2.1. Study Design and Data
2.2. Measures
2.2.1. Sociodemographic Measures
2.2.2. Psychological Distress
2.2.3. Perceived Social Isolation
2.3. Statistical Analysis
3. Results
3.1. Sample Distribution and Bivariate Comparisons
3.2. Weighted Linear Regressions
4. Discussion
4.1. Limitations and Strengths
4.2. Intervention and Practice Implications
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
| HINTS | Health Information National Trends Survey |
| PHQ | Personal Health Questionnaire |
| PROMIS | Patient-Reported Outcomes Measurement Information System |
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| Full Sample | Heavy drinking occasions* | p-Value† | ||
| None (n=394) | 1+ (n=329) | |||
| M (SE) or n (%) | M (SE) or % | M (SE) or % | ||
| Age | 23.6 (0.05) | 23.3 (0.06) | 24.0 (0.06) | < .001 |
| Sex | < .001 | |||
| Male | 460 (47.9) | 50.3 | 49.7 | |
| Female | 263 (52.1) | 59.8 | 40.2 | |
| Sexual orientation | .012 | |||
| Lesbian/gay | 39 (4.5) | 61.8 | 38.2 | |
| Straight | 576 (84.7) | 53.8 | 46.2 | |
| Bisexual | 108 (10.8) | 55.1 | 44.9 | |
| Race/ethnicity | < .001 | |||
| Non-Hispanic White | 336 (53.3) | 50.6 | 49.4 | |
| Non-Hispanic Black | 94 (8.6) | 72.6 | 27.4 | |
| Hispanic | 202 (22.3) | 48.7 | 51.3 | |
| Non-Hispanic Asian | 60 (11.0) | 71.9 | 28.1 | |
| Non-Hispanic Other | 31 (5.0) | 68.6 | 31.4 | |
| Education level | < .001 | |||
| Less than high school | 21 (6.1) | 37.0 | 63.0 | |
| High school graduate | 100 (18.4) | 64.7 | 35.3 | |
| Some college | 202 (41.4) | 59.3 | 40.7 | |
| College graduate or more | 400 (34.1) | 48.5 | 51.5 | |
| Household income | < .001 | |||
| <$20,000 | 112 (18.3) | 47.7 | 52.3 | |
| $20,000-<$35,000 | 75 (9.9) | 54.0 | 46.0 | |
| $35,000-<$50,000 | 114 (14.6) | 60.3 | 39.7 | |
| $50,000-<$75,000 | 153 (19.4) | 64.7 | 35.3 | |
| $75,000-<$100,000 | 188 (27.1) | 59.4 | 40.6 | |
| $100,000+ | 81 (10.8) | 35.0 | 65.0 | |
| Adults in household | .170 | |||
| 1 | 157 (11.6) | 57.1 | 42.9 | |
| 2+ | 258 (88.4) | 55.0 | 45.0 | |
| HINTS Cycle | < .001 | |||
| 6 (2022) | 432 (66.8) | 63.7 | 36.3 | |
| 7 (2024) | 291 (33.2) | 38.3 | 61.7 | |
| Personal Health Questionnaire (PHQ)-4 score | 3.3 (0.04) | 3.12 (0.05) | 3.5 (0.06) | < .001 |
| PROMIS Social Isolation T-score | 49.6 (0.15) | 49.9 (0.21) | 49.2 (0.22) | .025 |
| Model 1 | Model 2 | |||||||
| 95% CI | 95% CI | |||||||
| B | SE | LL | UL | B | SE | LL | UL | |
| Intercept | 43.95*** | 0.77 | 42.41 | 45.48 | 43.52*** | 0.78 | 41.97 | 45.07 |
| Age | -0.11*** | 0.03 | -0.16 | -0.05 | -0.09** | 0.03 | -0.15 | -0.04 |
| Sex (ref.=female) | ||||||||
| Male | 1.32*** | 0.22 | 0.88 | 1.76 | 1.34*** | 0.22 | 0.91 | 1.78 |
| Sexual identity (ref.=straight) | ||||||||
| Lesbian/Gay | 5.39*** | 0.59 | 4.22 | 6.56 | 1.34*** | 0.22 | 0.91 | 1.78 |
| Bisexual | 1.49*** | 0.34 | 0.82 | 2.16 | 1.34* | 0.22 | 0.91 | 1.78 |
| Race/ethnicity (ref.=NH White) | ||||||||
| Non-Hispanic Black | -3.71*** | 0.64 | -4.99 | -2.43 | -3.60*** | 0.64 | -4.87 | -2.33 |
| Hispanic | -1.92*** | 0.24 | -2.40 | -1.44 | -1.93*** | 0.24 | -2.41 | -1.45 |
| Non-Hispanic Asian | 1.17* | 0.49 | 0.19 | 2.14 | 1.36** | 0.50 | 0.37 | 2.36 |
| Non-Hispanic Other | 4.26*** | 0.47 | 3.34 | 5.19 | 4.20*** | 0.47 | 3.27 | 5.12 |
| Education level (ref.=college graduate or more) | ||||||||
| Less than high school | -1.40* | 0.62 | -2.63 | -0.18 | -1.51* | 0.63 | -2.75 | -0.26 |
| High school graduate | 0.15 | 0.29 | -0.42 | 0.72 | 0.33 | 0.29 | -0.25 | 0.92 |
| Some college | -0.01 | 0.26 | -0.53 | 0.51 | 0.05 | 0.27 | -0.47 | 0.58 |
| Household income (ref.=$100,000+) | ||||||||
| <$20,000 | 2.79*** | 0.50 | 1.80 | 3.78 | 2.77*** | 0.50 | 1.78 | 3.77 |
| $20,000-<$35,000 | -1.41** | 0.48 | -2.36 | -0.46 | -1.49** | 0.48 | -2.44 | -0.54 |
| $35,000-<$50,000 | 1.47** | 0.51 | 0.45 | 2.49 | 1.29* | 0.51 | 0.28 | 2.31 |
| $50,000-<$75,000 | -0.16 | 0.50 | -1.15 | 0.84 | -0.34 | 0.49 | -1.31 | 0.62 |
| $75,000-<$100,000 | 0.30 | 0.47 | -0.63 | 1.23 | 0.26 | 0.47 | -0.67 | 1.19 |
| Adults in household (ref.=2+) | ||||||||
| 1 | 0.18 | 0.25 | -0.32 | 0.68 | 0.19 | 0.26 | -0.32 | 0.69 |
| HINTS Cycle (ref.=7[2024]) | ||||||||
| 6 (2022) | 0.62* | 0.30 | 0.02 | 1.22 | 0.68* | 0.30 | 0.08 | 1.28 |
| Personal Health Questionnaire (PHQ)-4 score | 2.15*** | 0.05 | 2.04 | 2.26 | 2.15*** | 0.05 | 2.04 | 2.26 |
| Heavy drinking occasions (ref.=0) | ||||||||
| 1+ | -1.34*** | 0.19 | -1.72 | -0.95 | -1.16*** | 0.21 | -1.57 | -0.75 |
| Interaction (ref.= Heavy drinking occasion=1+ * straight) | ||||||||
| Heavy drinking occasion=1+ * lesbian/gay | -5.90*** | 0.98 | -7.84 | -3.95 | ||||
| Heavy drinking occasion=1+ * bisexual | 0.92 | 0.56 | -0.19 | 2.04 | ||||
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