Orthodontic treatment can be safely performed during pregnancy when tailored to the patient’s hormonal, physiological, psychological, and oral health changes. The study aims to establish a safe, trimester – specific orthodontic protocol that minimizes maternal – foetal risks while ensuring effective treatment. A systematic PubMed search using combined keywords and subtopic – specific queries was performed to identify relevant literature on orthodontics during pregnancy. Most studies were literature reviews, followed by various observational, survey – based, clinical, and case report designs. Orthodontic care during pregnancy must be adapted to trimester – related risks, with minimal interventions in the first trimester, elective procedures in the second, comfort focused management in the third, and treatment of complex care postpartum. This protocol requires individual adaptation, highlighting the need for personalized medicine and coordinated input from multiple specialists to address orthodontic, obstetric, and psychological factors during pregnancy.