This research examines how rising pressures from global risks, including natural disasters, geopolitical conflicts, cybercrime, and government regulations, affect sustainable supply chains and logistics systems. These pressures are becoming more frequent, intense, and unpredictable. The Global Pressure Supply Chain Index, developed by the Federal Reserve Bank of New York, serves as a proxy for quantifying these pressures and as a comprehensive metric of stress within global supply chains and logistics systems driven by macroeconomic factors. Further investigation is warranted. Quantitative analyses indicate that systemic global risks have a significantly positive effect on these systems. However, additional analyses show that the influence of macroeconomic indicators on these systems remains generally low to moderate. Supplementary statistical tests demonstrate that, among external systemic risks, government trade regulations, cybercrimes, cyberattacks, the transportation index, and political conflicts are significant predictors of pressures on global supply chains and logistics. These factors serve as indicators for forecasting economic fluctuations, which lead to disruptions, delays, and costs in supply chains and logistics systems.