Restoring Meaning to Healthcare: The ReGEN Framework for Biological Relativity and Tripartite Coherence in Regenerative Health: A Systematic Narrative Review

Background: The escalating global burden of complex chronic diseases and severe mental health challenges represents a significant limitation of reductionist healthcare paradigms. We propose that health is not merely the absence of disease, but rather a dynamic state of coherence across three integrated domains: biological, psychological, and noetic (consciousness-related). This review evaluates emerging technologies and interventions designed to restore this tripartite coherence. Objective: To systematically synthesize and critically evaluate the scientific evidence for technologies and interventions aligned with the ReGEN framework's seven pillars: Light, Water, Frequency, Energy, Breath, Intention, and Food. Methods: Following PRISMA guidelines, we conducted a systematic literature search across PubMed, IEEE Xplore, PsycINFO, and Cochrane Library (2010-2024). Included studies were evaluated against five criteria: biophysical plausibility, evidence quality, biomarker correlates, safety profile, and transdisciplinary alignment. Technologies were graded (A-D) based on evidence strength. Results: From 2,148 identified records, 215 studies met inclusion criteria after systematic screening. Our analysis identified a "Foundational Triad" of interventions with the strongest mechanistic plausibility and evidence base: Photobiomodulation (Light Pillar, Grade A), Coherent Breathing (Breath Pillar, Grade A), and Focused Intention (Intention Pillar, Grade B). These pillars demonstrate significant combined potential for initiating systemic healing cascades. Technologies targeting the Frequency and Energy pillars showed more preliminary evidence (Grade B-C), requiring further rigorous validation. Conclusion: The ReGEN framework provides a thorough transdisciplinary taxonomy for classifying and evaluating coherence-enhancing technologies. Convergent evidence across multiple scientific disciplines supports the complementary application of photobiomodulation, coherent breathing, and focused intention as a potent, non-invasive approach for restoring systemic coherence. This synthesis outlines a verification protocol via a Tripartite Coherence Index and identifies critical research priorities for advancing this emerging paradigm.