Submitted:
21 August 2025
Posted:
22 August 2025
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Abstract
Keywords:
1. Introduction
1.1. Population Segmentation in Health & Healthcare Systems
1.2. International Context
1.3. Local Context
1.4. Care Model Implications for Health System Population Segmentation Models
1.5. Systemic Health System Population Segmentation—Singapore Case Study
- Introduce a novel Systemic Health System Population Segmentation Model approach that is person-centred and needs-based to enable health system redesign.
- Describe the Lifelong Care Segmentation and Sub-segmentation Models for the macrosystem and mesosystem levels of the Service Delivery System of a health system, based on the UCM.
- Describe the Episodic Care Segmentation Model for the mesosystem and microsystem levels of the Service Delivery System of a health system, based on the UCM.
- Illustrate the development process and evaluation results of these models.
2. Materials and Methods
2.1. Lifelong Care Segmentation (LS) Model Development
2.2. Further Needs-Based Sub-Segmentation Model (NBSSM) Development
2.3. Episodic Care Segmentation (ES) Model Development
2.4. Health System Population Segmentation Model Evaluation
3. Results
4. Discussion
5. Conclusions
Author Contributions
Acknowledgments
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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| Disease Description | ICD-10 | Disease Description | ICD-10 |
|---|---|---|---|
| Chronic liver disease | B18, K70-K77, Z94 | Cancer | C00-C75 |
| Solid tumor | C76-C80 | Lymphoma | C81-C90, C96 |
| Leukaemia | C91-C95 | Diabetes | E10-E14, O24 |
| Hyperlipidemia | E78 | Dementia | F00-F03 |
| Schizophrenia | F20 | Bipolar | F30-F31 |
| Depression | F32-F34, F38-F39 | Anxiety | F40-F45 |
| Paraplegia | G04, G11 | Parkinson | G20 |
| Alzheimer’s disease | G30 | Epilepsy | G40-G41 |
| Transient ischemic attacks | G45, I65-I66 | Stroke | G46 |
| Paraplegia | G81-G83 | Visual impairment | H53-H54, Z44, Z97 |
| Hearing impairment | H90-H91, Q16 | Hypertension | I10-I13, I15, O10-011 |
| Ischemic heart disease | I20-I25 | Atrial Fibrillation | I48 |
| Heart failure | I50 | Stroke | I60-I64, I67, I69 |
| Peripheral vascular disease | I70-I74, I77, I79 | COPD | J41-J44 |
| Asthma | J45-J46 | Peptic ulcer disease | K25-K28 |
| Psoriasis | L40 | Rheumatoid arthritis | M05-M06, M08 |
| Osteoarthritis | M15-M19 | Connective tissue | M30-M36 |
| Osteoporosis | M80-M82 | Nephritis | N02-N08, N11, N14-16 |
| Renal failure | N18-N19, N25, Z49, Z99 | Hyperplasia of prostate | N40 |
| A: Early Disease | B: Advanced Disease | ||
|---|---|---|---|
| 1 | Single Chronic Disease or Frail only |
A1)
|
B1)
|
| 2 | Multiple Chronic Diseases |
A2)
|
B2)
|
| 3 | Multiple Chronic Disease + Mental Issues |
A3)
|
B3)
|
| 4 | Multiple Chronic Diseases + Social Issues |
A4)
|
B4)
|
| 5 | Multiple Chronic Illness + Mental + Social Issues |
A5)
|
B5)
|
| LS1 | LS2 | LS3 | LS4 | LS5 | LS6 | LS7 | P-value | |
|---|---|---|---|---|---|---|---|---|
|
Mean Age (Years) |
38.9 | 37.2 | 56.7 | 61.4 | 63.7 | 67.6 | 76.9 | <0.001 |
| Gender | ||||||||
| Female % | 49.3% | 49.9% | 50.3% | 56.9% | 44.6% | 49.6% | 46.7% | <0.001 |
| Ethnicity | ||||||||
| Chinese, % | 59.9% | 30.3% | 68.8% | 65.9% | 62.2% | 60.6% | 69.6% | <0.001 |
| Malay, % | 11.5% | 39.0% | 11.9% | 16.3% | 16.5% | 18.8% | 13.1% | |
| Indian, % | 11.9% | 14.5% | 10.5% | 10.7% | 13.3% | 12.7% | 7.0% | |
| Others, % | 16.7% | 16.2% | 8.8% | 7.1% | 8.0% | 7.9% | 10.3% | |
| Average CCI score | 0.4 | 0.4 | 2.2 | 3.1 | 5.1 | 6.4 | 8.8 | <0.001 |
| A1 | A2 | A3 | A4 | A5 | B1 | B2 | B3 | B4 | B5 | P-value | |
|
Mean Age (Years) |
49.3 | 62.1 | 58.2 | 63.5 | 65.4 | 47.0 | 65.2 | 68.6 | 65.2 | 71.6 | <0.001 |
| Gender | |||||||||||
| Female % | 52.6% | 48.4% | 57.1% | 51.4% | 65.3% | 48.3% | 43.9% | 57.9% | 42.5% | 54.4% | <0.001 |
| Ethnicity | |||||||||||
| Chinese, % | 65.5% | 71.9% | 72.4% | 58.5% | 67.3% | 56.6% | 62.9% | 68.7% | 53.6% | 64.6% | <0.001 |
| Malay, % | 13.0% | 11.0% | 10.5% | 22.1% | 13.1% | 17.5% | 16.0% | 11.1% | 24.8% | 15.4% | |
| Indian, % | 11.0% | 10.0% | 9.8% | 11.8% | 12.5% | 13.4% | 13.7% | 13.6% | 12.7% | 14.2% | |
| Others, % | 10.5% | 7.0% | 7.3% | 7.6% | 7.1% | 12.5% | 7.3% | 6.6% | 8.9% | 5.9% | |
| Average CCI score | 1.2 | 2.9 | 2.7 | 3.3 | 3.7 | 1.8 | 5.4 | 6.1 | 6.2 | 7.3 | <0.001 |
| A1 | A2 | A3 | A4 | A5 | B1 | B2 | B3 | B4 | B5 | P-value | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Average No. of ED visits | 0.6 | 0.4 | 0.9 | 0.9 | 1.6 | 0.7 | 0.7 | 1.3 | 1.1 | 2.1 | <0.001 |
| Average No. of SOC visits | 2.0 | 2.7 | 3.0 | 3.5 | 3.7 | 2.6 | 3.4 | 3.5 | 4.9 | 4.8 | <0.001 |
| Average No. of inpatient admission | 0.3 | 0.4 | 0.5 | 0.7 | 1.0 | 0.6 | 0.7 | 1.1 | 1.3 | 2.0 | <0.001 |
| Average annual hospitalization bed days | 0.7 | 0.8 | 2.3 | 4.8 | 9.5 | 2.8 | 2.7 | 8.1 | 9.9 | 22.6 | <0.001 |
| Average annual overall healthcare cost (SGD) | $1,941 | $2,538 | $3,981 | $6,955 | $10,682 | $5,432 | $6,018 | $10,399 | $14,524 | $23,356 | <0.001 |
| ES1 | ES2 | ES3 | ES4 | ES5 | ES6 | P-value | |
|---|---|---|---|---|---|---|---|
|
Number of cases (%) |
1,966 (11.7%) |
5,807 (34.6%) |
4,215 (25.1%) |
1,274 (7.6%) |
722 (4.3%) |
351 (2.1%) |
|
| Average length of stay (Day) | 2.2 | 4.3 | 8.2 | 6.7 | 11.8 | 10.7 |
<0.001 |
| Average inpatient admission cost (SGD) | $3,283 | $5,571 | $8,384 | $14,314 | $17,298 | $10,655 | <0.001 |
| 30-day emergency readmission rate | 1.4% | 5.3% | 16.3% | 6.8% | 16.1% | 29.9% | <0.001 |
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