The Structural Units (SU) system introduces a new measurement framework by defining units based on quantized spacetime distances and delays, providing a fixed reference absent in the International System of Units (SI). This approach simplifies Fundamental constants, expressing them through pure numbers like π, φ, and α, and offers a theoretical basis for their values instead of relying on CODATA assignments. To test SU’s compatibility with SI, Planck Units are recalculated in SU and converted via dimensional analysis. An experimental validation is proposed using the SI-based Kibble balance, ensuring converted physical quantities align precisely. SU also reconciles Relativity, Quantum Mechanics, and Thermodynamics by demonstrating that energy, mass, and temperature emerge from the same structural principles, providing a consistent interpretation of entropy and gravitational thermodynamics. Additionally, SU is applied to key physics concepts, including the Schwarzschild radius, photon energy, and the Uncertainty Principle. Finally, we explore the implications of Spacetime discretization by modifying fundamental equations, such as those of Schrödinger, Dirac, and General Relativity, replacing continuous derivatives with discrete ones to reflect a granular spacetime. If confirmed, SU would offer a reproducible framework for laboratories to explore Cosmology and new technological applications.