Interdisciplinary research (IDR) has the potential to drive scientific innovation, economic development, and sustainable solutions to Africa’s complex challenges. By integrating knowledge across disciplines, IDR fosters holistic approaches to pressing issues such as public health crises, food security, climate change, and technological innovation. However, its implementation in Africa is hindered by structural, institutional, and financial barriers. Rigid academic frameworks, disciplinary silos, and limited funding impede collaboration, while inadequate research infrastructure, fragmented data-sharing mechanisms, and policy inconsistencies further stifle interdisciplinary engagement. Additionally, sociocultural and political challenges—including language barriers, historical power imbalances, and political instability—complicate efforts to build inclusive and effective research communities. To address these challenges, this paper explores key strategies for strengthening IDR in Africa. These include fostering collaborative research cultures, enhancing interdisciplinary training programmes, and leveraging regional and international networks to facilitate knowledge exchange. The establishment of unified regulatory frameworks, streamlined ethical review processes, and interdisciplinary funding mechanisms is essential to sustaining IDR efforts. Furthermore, capacity-building initiatives—such as specialised fellowships, mentorship programmes, and Intellectual Property (IP) management training—are critical for equipping researchers with the skills necessary for effective interdisciplinary collaboration. By investing in IDR through policy advocacy, institutional reforms, and increased funding, African nations can harness the transformative power of interdisciplinary science to bridge knowledge gaps, stimulate innovation, and address the continent’s most pressing development challenges. A coordinated effort among governments, academic institutions, industry stakeholders, and international partners is imperative to fostering an enabling environment for IDR.