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Sodium Zirconium Cyclosilicate in the Gastrointestinal Tract Mimicking an Acute Gastrointestinal Bleed on CT

This version is not peer-reviewed.

Submitted:

18 March 2025

Posted:

19 March 2025

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Abstract
Background and Clinical Significance: Hyperattenuating contents in the gastrointestinal (GI) tract detected on CT scans are commonly seen, and are almost always due to the purposeful ingestion of an oral contrast agent, usually barium or iodine based, used for evaluating the GI tract. Occasionally, other ingested material such as antacids or other medications, foreign objects, and medical devices, can also be hyperattenuating. While these are usually correctly identified, there is the potential for misdiagnosis of such material as a pathologic condition. Lokelma (sodium zirconium cyclosilicate (SZC)) is an agent which is being increasingly used to treat hyperkalemia, and which has a hyperattenuating appearance on CT due to the presence of zirconium, although this is not well not known to the radiologic community. We describe a case in which SZC was seen in the GI tract on CT, and misinterpreted as an acute GI bleed. Case Presentation: A 72-year-old woman underwent single (portal venous) phase intravenous contrast-enhanced abdominal and pelvic CT after presenting to the ED with a lower GI bleed. The CT showed intraluminal hyperattenuation within a loop of ileum which was diagnosed prospectively as an active GI bleed. A CT angiogram of the abdomen and pelvis performed the following day for follow-up showed the hyperattenuating contents to be present on the non-IV contrast enhanced series of the study, thereby proving that it was not due to active bleeding. Further investigation of the patient’s medical record showed that the patient was being treated with SZC for hyperkalemia. Conclusions: Sodium zirconium cyclosilicate (SZC) has a hyperattenuating appearance on CT. Knowledge of this appearance by radiologists and clinical staff can help avoid confusion and misdiagnosis.
Keywords: 
CT scan
;  
CT angiogram
;  
GI bleed
;  
lokelma
;  
sodium zirconium cyclosilicate
;  
hyperattenuating bowel contents
Subject: 
Medicine and Pharmacology  -   Other

1. Introduction and Clinical Significance

Hyperattenuating contents in the gastrointestinal (GI) contents on CT examinations of the abdomen, pelvis, or chest are commonly encountered, and almost always due to the purposeful ingestion of an oral contrast agent, usually barium or iodine-based, employed to aid in detection of gastrointestinal disease. Other, less common, sources of high attenuation in the lumen of the bowel include orally administered medications, such as antacids, foreign objects, and medical devices. Lokelma (sodium zirconium cyclosilicate (SZC)), a compound used to treat hyperkalemia, has a hyperattenuating appearance on CT and radiography due to the presence of zirconium, a transition metal in the periodic table. We report a patient in which SZC was seen in the GI tract as hyperattenuating material on CT, and which was initially mistakenly diagnosed as an acute GI bleed in the cecum. This phenomenon, and potential pitfall, is not well known to radiologists, to our knowledge.

2. Case Presentation

Case

A 72-year-old woman with multiple medical conditions, including end-stage renal disease on hemodialysis, presented to the Emergency Department with rectal bleeding. The patient was found to be hyperkalemic on admission (potassium of 5.7). The patient underwent single-phase portal venous phase CT of the abdomen and pelvis, performed with intravenous contrast and without positive oral contrast. The scan showed hyperattenuating contents in the cecum, which was interpreted by the attending radiologist to be contrast extravasation from an active gastrointestinal (GI) bleed (Figure 1A). There were no other acute or otherwise substantial findings on the scan, including no bowel wall thickening or mass. Based on this interpretation, a multi-phase CT angiogram of the abdomen and pelvis was performed the following day, in which similar intraluminal high density, measuring 1085 Hounsfield Units(HU), was seen in the cecum on the non-IV contrast enhanced series of the examination, performed prior to the administration of intravenous contrast, proving that this was not active bleeding (Figure 1B,C). The arterial and venous phase series from the CT angiogram showed no contrast extravasation anywhere in the GI tract to suggest an acute GI bleed. Subsequent discussion with the clinical team caring for the patient revealed that the patient was being treated with SZC for her hyperkalemia, which explained the source of the hyperattenuating material in the bowel.

3. Discussion

Positive oral contrast agents used for X-ray or computed tomography (CT) are usually barium or iodine-based. Additionally, there are a wide spectrum of orally administered medications that are radiopaque on CT, including prescribed drugs, over-the-counter remedies, and multivitamins[1,2]. The hyperattenuating property of a drug can be due to a variety of substances, including but not limited to iodine, iron, bismuth, potassium, sulfur, aluminum, and calcium. Theoretically, any material containing a high atomic number element or with high mass density could be hyperattenuating. Rarely, hyperattenuating medications can be the source of misdiagnosis on radiography or CT, potentially being mistaken for gallstones, nephrolithiasis, gastric bleeding, and foreign objects[3,4,5,6,7]. Sodium zirconium cyclosilicate (SZC) is a relatively new medication, approved by the United States Food and Drug Administration in 2018. While it has been shown to be hyperattenuating on various imaging modalities[8,9,10,11,12], there is a paucity of literature and lack of knowledge among clinicians and radiologists regarding this fact.
Several recent case reports in the medical literature have shown SZC to be very dense on CT[8,9,10,11], with attenuation similar to routinely used barium and iodine based oral contrast agents, and iodine-based intravenous contrast. Additionally, since SZC is administered as a liquid suspension, it will have a more diffuse distribution in the bowel than pill-based medications, and thus can mimic oral contrast, although the quantity of SZC in the bowel would be expected to be less than that of a routine oral contrast preparation used for abdominal and pelvic CT examinations. Kolesnik et al. demonstrated high attenuation in vitro radiopacity of a solution of SZC and water on CT, with Hounsfield unit (HU) measurements ranging from 1040-1878 HU[8]. McCarney et al. showed significant alterations of bone mineral density measurements on dual-energy X-ray absorptiometry (DXA) scan when scanning SZC solutions of varying concentrations with spine and body phantoms[12]. However, none of these publications were in the imaging literature.
SZC has been shown to effectively treat hyperkalemia, with low risk of hypokalemia, and favorable tolerability and safety profiles compared to placebo. It is an inorganic, insoluble, non-polymer zirconium silicate compound that binds potassium and ammonium cations in the gastrointestinal tract in exchange for hydrogen and sodium cations, allowing for the excretion of potassium through the GI tract. The beneficial potassium-lowering effects can be utilized in patients with chronic kidney disease, heart failure, diabetes mellitus, and concomitant use of medications targeting the renin-angiotensin-aldosterone-system, and maintained for up to 12 months [13]. It is not absorbed in the GI tract [14].
The hyperattenuating effect of SZC is due to zirconium, which has an atomic number of 40. Higher atomic number elements have a greater number of electrons with which photons may interact, and a denser electron cloud, and therefore attenuate a higher proportion of the X-ray beam than lower atomic number elements. By way of comparison, the atomic numbers of barium and iodine are 56 and 53 respectively. Of note, the attenuation of SZC in the case patient was qualitatively similar to barium oral contrast and iodine-based oral and intravenous contrast agents on CT, and did not cause any noticeable beam hardening artifact from its opacity.
Although the general radiological community may not be familiar with the imaging appearance of zirconium, it is commonly used in dentistry in the form of zirconia, an oxidized form of zirconium, which has metal and non-metal properties and is the basis for ceramic based implants. The imaging appearance of zirconium and titanium-based implants, as well as their potential to cause image-degrading artifacts, is well documented in the dental literature.[15,16,17]
The clinical utilization of SZC is on the rise, and radiologists are therefore more likely to encounter SZC in the GI tract on CT examinations. Knowledge regarding the imaging appearance of SZC is important, as it can be the cause of otherwise unexplained high attenuation in the GI tract on CT in a patient being treated for hyperkalemia. Moreover, SZC could potentially lead to misdiagnosis, as it initially did in our patient, in which the presence of SZC was mistaken for acute gastrointestinal hemorrhage. This is an important consideration in a patient in which a CT examination is performed only with intravenous contrast-enhanced images. A CT angiography performed for evaluation of acute GI bleeding typically consists of both non-enhanced and IV contrast-enhanced (usually arterial and more delayed phase) acquisitions. The non-enhanced series is essential to avoid misdiagnosis of commonly found hyperattenuating material, including surgical clips, suture, stents and residual oral contrast from prior CT scans, as active bleeding, as it effectively did in our patient.[18] Alternatively, SZC may obscure the presence of intraluminal contrast extravasation in a patient experiencing acute GI bleeding. The high attenuation of SZC could also hinder evaluation of mural abnormalities of the intestine, such as perforation, enteritis, ischemia or neoplasm, or could be mistaken for an ingested foreign object.

4. Conclusion

We present a case of hyperattenuating contents in the GI tract on CT scan due to lokelma (sodium zirconium cyclosilicate), a relatively new potassium lowering agent. Recognition of SZC as a potential source for high density in the GI tract may help reduce confusion amongst clinicians and radiologists when seen on CT, and could potentially avoid non diagnostic or erroneous interpretations of CT scans for bowel related disease.

Author Contributions

Conceptualization, JJH.; methodology, JJH, JR; writing—original draft preparation, JR; review and editing, JJH, DSK.; supervision, JJH, DSK. All authors have read and agreed to the published version of the manuscript.

Funding

This paper received no external funding.

Institutional Review Board Statement

Ethical review and approval were not required because case reports are not considered research. The patient’s information has been de-identified.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflicts of interest.

Abbreviations

The following abbreviations were used in this manuscript:
CT Computed Tomography.
SZC Sodium Zirconium Cyclosilicate.
GI Gastrointestinal.
DXA Dual-energy X-ray absorptiometry.
HU Hounsfield Unit.

References

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Preprints 152812 g001
Figure 1. 72-year-old woman with rectal bleeding. Axial intravenous contrast-enhanced image from single phase CT (a) shows high attenuation in the cecum (arrows), which was interpreted as active bleeding. Non-IV contrast (b) and arterial phase (c) images from CT angiogram performed one day later again shows hyperattenuating contents (arrows), similar in volume and distribution to the previous CT scan and without change between the two series, proving that the high attenuation was ingested material rather than intravenous contrast extravasation.
Figure 1. 72-year-old woman with rectal bleeding. Axial intravenous contrast-enhanced image from single phase CT (a) shows high attenuation in the cecum (arrows), which was interpreted as active bleeding. Non-IV contrast (b) and arterial phase (c) images from CT angiogram performed one day later again shows hyperattenuating contents (arrows), similar in volume and distribution to the previous CT scan and without change between the two series, proving that the high attenuation was ingested material rather than intravenous contrast extravasation.
Preprints 152812 g001
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Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.

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