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Thiol-epoxy Click Chemistry: The Synthesis of Vicinal Amino Alcohols Containing 1,2,4-Triazole Ring
This version is not peer-reviewed.
Submitted:
13 March 2025
Posted:
13 March 2025
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Abstract
As examples of “Click Chemistry”, the reaction of 1-(oxiran-2-ylmethyl)piperidine with several 1,2,4-triazoles derivatives was studied. According to as a result, the reaction shows that the oxirane ring opens regiospecifically, according to Krasusky’s rule, without using a catalyst. The basic nitrogen present in 1-(oxiran-2-ylmethyl)piperidine has a catalytic (anchimer) effect.
Keywords:
Click chemistry
; thiol-epoxy reaction
; bis-1
; 2
; 4-triazole
; vicinal amino alcohols
; Krasusky rule
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