Preprint
Article

This version is not peer-reviewed.

Behavioral Implications of COVID-19 Prevention and Vaccination Status in Africa During 2023

Submitted:

22 November 2024

Posted:

27 November 2024

You are already at the latest version

Abstract
COVID-19 remains a global health emergency, causing thousands of illnesses. This study investigated peoples’ knowledge of COVID-19 in Africa. It highlighted factors impacting acceptance of preventive and vaccination measures. This cross-sectional survey was conducted in Nigeria, and South Africa, from September 2023 to December 2023. It included 1000 participants via convenience sampling. Participants completed the validated survey online or in person. Data was analyzed using t-test, analysis of variance, regression analysis, Pearson Chi-square test, and Fisher's exact test. Most participants (96%) identified COVID-19 as a virus and were aware of its transmission modes. About 60% reported using facemasks and hand hygiene as preventative measures. Education, employment status, and living arrangements significantly influenced knowledge of COVID-19. Despite 88% of participants being aware of vaccines, 21% had received the first vaccine dose, and 81.7% had negative attitudes towards vaccinations. False information was the leading hindrance, especially in younger and less-educated individuals, who believed that the vaccine caused death (26%) or caused COVID-19 itself (17%). Therefore, future interventions should address misconceptions about vaccines and widen access to preventative measures. Further research should examine behavioral interventions to improve compliance with infection control measures.
Keywords: 
;  ;  ;  ;  ;  

Introduction

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Most infected people experience mild to moderate respiratory illness and recover without special treatment. However, some people become seriously ill or die [1]. COVID-19 was declared a pandemic by the World Health Organization (WHO) in March 2020 [2,3]. COVID-19 has overwhelmed the health systems of many countries, caused significant deaths, and caused enormous economic losses. To date, COVID-19 has infected millions of people and caused millions of deaths worldwide [3]. Efforts have been made to mitigate the devastating effects of this unprecedented global health crisis. The WHO recommends disease control measures such as personal protective equipment, hand hygiene, physical distancing, and vaccination [3,4,5]. The WHO recommends vaccination to prevent severe disease and reduce the likelihood of new variants emerging [5,6]. However, compliance with vaccination recommendations poses significant challenges in controlling the spread of the disease.
COVID-19 vaccine acceptance rates differ globally, with the highest rates in Ecuador (97%), Malaysia (94%), and Indonesia (93%), and the lowest in Lebanon (21%) [6]. COVID-19 vaccine hesitancy is widespread and influenced by various factors such as perceived infection risk, vaccine safety, vaccine efficacy, doctors' recommendations, and inoculation history [7]. Predictors of COVID-19 vaccine hesitancy include lower perceived risk of infection, institutional mistrust, lack of influenza vaccination, lower perceived severity of COVID-19, beliefs that vaccination will cause side effects, or beliefs that vaccines are unsafe [8].
African studies have demonstrated variability in knowledge and attitudes towards COVID-19 transmission and control. Additionally, studies have shown gaps between knowledge and practice of preventive guidelines and vaccine acceptance [9,10]. Studies in sub-Saharan African countries showed vaccine hesitancy was significantly associated with participant’s gender, educational level, occupational status, attitude towards COVID-19 preventive measures, and primary information source being social media [11,12].
COVID-19 remains a global health emergency, causing thousands of illnesses and deaths [13]. The current study aims to analyze public knowledge and beliefs about COVID-19 disease, compliance with control measures, and vaccination in Africa. A pilot study was completed in 2021 to validate the questionnaire for collecting data in the final survey conducted in 2023. The study's objective is to analyze the public's knowledge of COVID-19 disease, factors influencing the practice of preventive measures, and vaccine acceptance towards making recommendations for better policies. The study is part of regional efforts to improve public health in the countries where the studies were conducted.

Materials and Methods

Study Design

This is a cross-sectional survey of the general population in the selected African cities of Port Harcourt, Nigeria, and Port Elizabeth, South Africa. It included people from all walks of life, ages, literacy levels, and professions. Participants were selected by convenience sampling. Those who refused to participate were excluded from the study. The South African Eastern Cape Department of Health approved the survey. One thousand participants were recruited via convenience sampling.

Data Collection

The study was conducted from September to December 2023. The study was questionnaire-based. The questionnaire was validated in a pilot study in 2021. Adjustments were made based on the preliminary data to ascertain that the responses reflected the questions asked and that the questions reflected the study’s objectives. The validated questionnaire was administered partly online and partly in person in 2023. Data collectors administered the questionnaire in person to people in public places. The online questionnaire was disseminated via the research collaborators’ social media accounts, including WhatsApp Messenger, Facebook, and LinkedIn.
Questions included sociodemographic data, knowledge of COVID-19 transmission, control, and remedies. Questions were designed in a multiple-choice format where participants were instructed to choose one or more options. For questions with only one answer choice, the correct answer was allotted one point. Each correct answer is given one point for questions with possible multiple correct answers. No point was given for incorrect responses. The total score was 22 points. A score of less than 11 (50%) was graded as poor, and a score greater than 50% was graded as good.
Knowledge about the COVID-19 vaccine was assessed, including vaccine type, preference, vaccination status, safety, efficacy, benefits, adverse effects, and vaccine ingredients. Questions on vaccine safety, effects, ingredients, and adequacy of vaccine testing were formulated in a Yes, No, and Not Sure format, instructing participants to choose only one option. Questions were graded and given 1 point for each correct answer. A total score of < 50% was graded as poor, and a total score of >50% was graded as good.

Data Analysis

Data was analyzed using IBM® SPSS® Statistics 28 (IBM Corp, Armonk, NY) through Student's t-test, analysis of variance, regression analysis, Pearson Chi-square test, and Fisher's exact test. Continuous variables such as age, knowledge score, and attitude score were converted into appropriate categories and analyzed using proper methods. Multivariate analysis was conducted using logistic regression for knowledge about COVID-19 and attitudes toward vaccines to determine predictors. A P-value <0.05 was considered significant. Quantitative and qualitative data are presented in tables, including numbers, categories, and percentages. The data were compared, analyzed, and interpreted appropriately.

Ethical Consideration

The study aims were explained to the participants. No coercion was used in the recruitment process. Participants were informed about the rationale and purpose of the research and signed an informed consent form before participating in the study.

Results

Table 1 provides an overview of the demographics of the study population. The largest age group in the study (68%) was early adult (20-49 years). Females make up the majority of the study population (57%). Most of the study population have completed either secondary education (31%) or a college/university degree (50%). People living with their spouse or small family comprise 47% of the population, while 30% live alone. More than half of the population (52%) are unemployed; the remainder are employed full-time or part-time. Students comprise 31% of the population, and office work is the second most common occupation, constituting 19%.
In Table 2, an overview of the knowledge of the study population regarding COVID-19 is provided. Most of the population (96%) correctly identified that a virus causes it, and 94% recognized cough as the primary transmission mode. Of those who suggested a treatment, 42% mentioned vaccination, while 35% stated no cure. Most people believed COVID-19 could affect any country (86%) and anyone (87%). The most commonly listed preventive measures were facemask use (72%) and practicing good hand hygiene (61%).
Table 3 presents the knowledge of the study population concerning COVID-19 vaccines. According to the data, AstraZeneca is the most recognized vaccine with a recognition rate of 75%, while Pfizer ranks second with a recognition rate of 20%. Approximately 12% of the study population is not aware of any vaccine. Additionally, 21% of respondents have received the first dose of the COVID-19 vaccine, while only 4.4% have received the second dose. According to the study, 45% of people who are aware of the available vaccines prefer AstraZeneca, with 96% citing efficacy as the primary reason. Most of the population (56%) believe the vaccine is safe, while 41% believe it has minor side effects. Additionally, 63% of respondents reported that older adults would benefit from the vaccine, and 59% thought it is suitable for hospital workers.
Table 4 summarizes the association between the level of knowledge about COVID-19 and sociodemographic parameters. The study reveals a significant association between knowledge about COVID-19 and participants' education level, living status, job status, and job type. The majority of participants with secondary and college/university education demonstrated good knowledge, while the majority of participants with vocational/technical education were reported to have poor knowledge. About 63% of individuals living with a spouse or a small family had good knowledge. Full-time employment was associated with a higher level of knowledge about COVID-19. Among the participants, most business owners/executives, essential workers not in healthcare, and labor workers had good knowledge. In contrast, 61% of healthcare workers were found to have poor knowledge about the cause and disease control variables of COVID-19.
Table 5 depicts the logistic regression analysis of factors associated with poor knowledge of COVID-19. Among the list of sociodemographic parameters, vocational/technical education, unemployment, and being a healthcare worker were significantly associated with inadequate knowledge.
Table 6 shows the association between sociodemographic characteristics and attitudes toward the COVID-19 vaccine. The study showed a significant association between attitudes toward the COVID-19 vaccine and participants' age, education level, living situation, and employment status. Gender and job type were not found to have a significant association. At least 90% of participants aged 13-19 years, participants with vocational/technical education, and those who live in a congregation were found to have poor attitudes towards the vaccine.
Table 7 depicts the logistic regression analysis, including factors associated with attitude level. It presents adjusted OR and p-values for each modality of categorical variables. Unemployment since COVID and before COVID is significantly related to poor attitude (OR=2.89 and OR=2.04, respectively); meaning it is a risk factor for poor attitude. Age above 20 years was protective against poor attitude (OR < 1, p < 0.05). Additionally, living alone or in a small family was protective against poor attitude. Modalities without OR and p-values are reference modalities considered in the analysis.

Discussion

Based on our study, many participants showed a good understanding of the COVID-19 disease. A high percentage (96%) correctly identified the causative organism as a virus, and most also recognized physical contact and respiratory droplets as the primary modes of transmission. A significant portion of the population (42%) identified vaccines as the most effective form of management. The well-informed nature of our study population may be attributed to the online data collection which skewed towards individuals with more digital literacy and perhaps more aware of public health issues. The practical information campaigns conducted by the relevant authorities may also be a contributing factor. This finding aligns with studies conducted in other African countries, which also demonstrated a high level of COVID-19 knowledge among respondents [10,12].
Over 60% of the participants mentioned wearing a mask and practicing hand hygiene as preventive measures, while approximately 56% listed maintaining physical distance. Similar studies in other African countries also showed that awareness of preventive measures is high but compliance with these measures remains below optimal levels. Reasons for poor compliance include negative attitudes, lack of personal protective equipment, and limited access to potable water [10,14]. Many respondents expressed that COVID-19 is a significant public health issue in their country and can potentially affect anyone. Approximately 68% of the participants stated that their governments must improve COVID-19 control and management.
The current study revealed a strong link between COVID-19 knowledge and participants' education level, living arrangement, employment status, and job type. Specifically, vocational/technical education, unemployment, and being a healthcare worker were significantly associated with poor knowledge. People with secondary and college education generally displayed good knowledge about COVID-19, while those with vocational and technical education showed poor knowledge. Some studies in Tanzania, Ethiopia, and Uganda also found that higher education is associated with a better understanding of COVID-19 [11,15]. Additionally, a study in Nigeria found tertiary education is associated with a positive attitude [16].
The current study showed that most people living with a spouse or in a small family had good knowledge about COVID-19, a finding also supported by studies in Nigeria and Ethiopia where marital status was linked to good knowledge [16,17]. Our study also revealed that participants' job status and type were associated with their COVID-19 knowledge. Full-time employment was linked to higher levels of expertise, and 70% of business owners or executives exhibited good knowledge. In contrast, most healthcare workers (61%) were found to have poor knowledge. This is a unique and unexpected finding that contradicts studies conducted among healthcare workers in different African countries [11,15]. The discrepancy could be due to the undefined job description and education level of the healthcare workers in the study in contrast to participants in the comparative analyses.
Most of our study participants (88%) know about the COVID-19 vaccine. AstraZeneca is the most recognized and preferred vaccine among the participants. The increased availability of the AstraZeneca vaccine in Africa compared to other brands may be the reason. Most patients with a vaccine preference (96%) cited efficacy as the primary reason for their choice. Most participants believed the vaccine was suitable for older adults and healthcare workers. Approximately 56% of participants thought the vaccine was safe, and 40% felt it was tested well. Despite this finding, only 21% and 4.4% of the participants received the first and second doses of the COVID-19 vaccine, respectively. These findings show a discrepancy between participants’ knowledge about the vaccine and their decision to get vaccinated. This may be due to negative attitudes towards the vaccine or lack of vaccine availability.
Our study also showed that a majority (81.7%) of study participants, regardless of other socioeconomic characteristics, were found to have poor attitudes toward the vaccine. This finding demonstrates that participants' attitudes might significantly influence their decision to take the vaccine. Approximately 26% of participants reported that they believe that vaccines cause death, and 17% believed that vaccines cause COVID-19, which might have contributed to the negative attitude towards vaccines. This finding implies that there are more factors, in addition to concerns about vaccine safety and efficacy, that influenced participants' attitudes about the COVID-19 vaccine, since the majority of the study participants believed it was safe and 99.8% had a vaccine preference, citing efficacy as their reason for choice. This finding contrasts with other studies on vaccine acceptance in different African countries, which showed a lack of information about the vaccine and uncertainty about the efficacy and safety of the vaccine as the main reasons for vaccine hesitancy [17,19].
The current research revealed a strong association between people's attitudes toward the COVID-19 vaccine and their age, level of education, living situation, and employment status. A significant majority (96%) of individuals aged 13-19 years expressed negative attitudes toward the vaccine. Similar negative attitudes were observed among young participants in other studies examining COVID-19 vaccine perspectives and uptake [20,21].
A study conducted in Zambia stated that participants received information about the vaccine from social media [22]. Young participants believed they were not at risk of COVID-19, with misinformation from social media being identified as a possible factor [22]. Another study in Mozambique focusing on vaccine acceptance noted a strong correlation between institutional trust and vaccine acceptance [12]. The negative impact of social media on young people’s attitude towards the vaccine and its adverse effects on recommendations put out by the government might play a significant role in vaccine acceptance among this age group.
The current study showed that people with primary, vocational, or technical education also reported negative attitudes towards the vaccine. This aligns with other studies that showed individuals with secondary education or higher were more likely to accept the COVID-19 vaccine [23]. Furthermore, 96% of participants living in congregational settings demonstrated negative attitudes toward the vaccine. At the same time, at least 85% of individuals working part-time or unemployed were reported to have poor attitudes. Before and after COVID-19, unemployment was significantly associated with increased negative attitudes, as seen in a study on COVID-19 vaccine acceptance among sub-Saharan Africans, which indicated that unemployment was linked to a higher risk of vaccine resistance [24]. This might result from institutional grievances and mistrust affecting participants’ attitudes towards vaccine recommendations put out by their government.

Limitation

This study explored various sociodemographic factors, permitting a detailed analysis of knowledge and attitudes amongst a large and varied sample of ages, educational backgrounds, and occupational statuses. Online and in-person data collection maximized the inclusivity of the sample, enabling the gathering of diverse perspectives within the selected countries. However, convenience sampling may limit the representativeness of the data, with online data collection increasing the possibility of response bias, where individuals with greater digital competence are overrepresented, skewing results towards those who are more informed about public health campaigns.

Conclusions

Most of the population had a good understanding of COVID-19, with education, occupation, and living arrangements greatly influencing knowledge. Despite awareness of preventative measures, compliance was low due to negative attitudes and limited availability of preventative resources such as facemasks. Most of the population deemed the vaccine safe. However, a minority had concerns regarding the vaccine, including misunderstandings that the vaccine could cause COVID-19 itself.
Efforts should be made to correct misconceptions by providing accessible information about vaccine safety, particularly in communities with poor knowledge. The media and health authorities in the respective countries should work to address the institutional mistrust of health care systems which negatively affects peoples’ attitude towards public health measures recommended by the authorities. Another focus should be widening access to preventative resources. Further research should explore behavioral interventions that can increase compliance with these resources and explore other socioeconomic factors, such as job security, to create targeted policies.

Author Contributions

All the authors testify that all persons designated as authors qualify for authorship and have checked the article for plagiarism. If plagiarism is detected, all authors will be held equally responsible and bear the resulting sanctions imposed by the journal afterward. All authors contributed to the conceptualization, methodology, validation, formal analysis, investigation, data curation, writing of original draft preparation, writing of review and editing, and visualization. The corresponding author, provided supervision, project administration, and funding. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

This clinical study was approved by the South African Eastern Cape Department of Health, which confirmed that it is a quality assurance study and does not require a formal review by the research ethics board.

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Data Availability Statement

The dataset presented in the study is available on request from the corresponding author during submission or after publication.

Acknowledgments

None.

Conflicts of Interest

The authors declare no conflicts of interest.

References

  1. Khamis, F; Al-Zakwani, I; Al Naamani, H; Al Lawati, S; Pandak, N; Omar, MB; Al Bahrani, M; Bulushi, ZA; Al Khalili, H; Al Salmi, I; Al Ismaili, R; Al Awaidy, ST. Clinical characteristics and outcomes of the first 63 adult patients hospitalized with COVID-19: An experience from Oman. J Infect Public Health. 2020; 13:906-913. [CrossRef]
  2. Bamgbade, OA; Magboh, VO; Otegbeye, AU; King, MB; Oluwole, OJ; Olatunji, BT. Difficult tracheal extubation due to endotracheal tube malfunction: A challenge during the COVID-19 pandemic. J Taibah Univ Med Sci. 2021; 16:935-937. [CrossRef]
  3. Khamis, F; Al Awaidy, S; Ba'Omar, M; Osman, W; Chhetri, S; Ambusaid, Z; Al Fahdi, Z; Al Lawati, J; Al Sulaimi, K; Al Bulushi, SA; Al Bahrani, M; Al-Zakwani, I. The Impact of Demographic, Clinical Characteristics and the Various COVID-19 Variant Types on All-Cause Mortality: A Case-Series Retrospective Study. Diseases. 2022; 10:100. [CrossRef]
  4. Bamgbade, OA; Richards, RN; Mwaba, M; Ajirenike, RN; Metekia, LM; Olatunji, BT. Facial topical cream promotes facemask tolerability and compliance during COVID-19 pandemic. J Taibah Univ Med Sci. 2022; 17:441-447. [CrossRef]
  5. Al Busaidi, BH; Al Riyami, IM; Wazir, HB; Al Zakwani, IS. Analysis of COVID-19 Vaccine Adverse Drug Reactions Reported Among Sultan Qaboos University Hospital Staff. Sultan Qaboos Univ Med J. 2024; 24:216-220. [CrossRef]
  6. Shakeel, CS; Mujeeb, AA.; Mirza, MS.; Chaudhry, B.; Khan, SJ. Global COVID-19 Vaccine Acceptance: A Systematic review of associated social and Behavioral factors. Vaccines 2022, 10. [CrossRef]
  7. Hassan, MM; Al Yazidi, L; Elsidig, N; Al Falahi, M; Salmi, N; Al-Jaffari, Y; Al-Amri, L; Zeiidan, H; Al-Zakwani, I. COVID-19 Vaccine Hesitancy among Parents of Children Younger than 12 Years: Experience from a Tertiary Outpatient Clinic. Pharmacy (Basel). 2024; 12:85. [CrossRef]
  8. Pires, C. Global Predictors of COVID-19 Vaccine Hesitancy: A Systematic review. Vaccines 2022, 10. [CrossRef]
  9. Khamis, F; Al Rashidi, B; Al-Zakwani, I; Al Wahaibi, AH; Al Awaidy, ST. Epidemiology of COVID-19 Infection in Oman: Analysis of the First 1304 Cases. Oman Med J. 2020; 35(3):e145. [CrossRef]
  10. Matovu, J. K.; Mulyowa, A.; Akorimo, R.; Kirumira, D. Knowledge, risk-perception, and uptake of COVID-19 prevention measures in sub-Saharan Africa: a scoping review. African Health Sciences 2022; 22, 542–560. [CrossRef]
  11. Abdullahi, I. N.; Emeribe, A. U.; Ajayi, O. A.; Oderinde, B. S.; Amadu, D. O.; Osuji, A. I. Implications of SARS-CoV-2 genetic diversity and mutations on pathogenicity of the COVID-19 and biomedical interventions. J Taibah Univ Med Sci. 2020; 15, 258-264.
  12. Hu, B; Yang, W; Bouanchaud, P; Chongo, Y; Wheeler, J; Chicumbe, S; Chissano, M. Determinants of COVID-19 vaccine acceptance in Mozambique: The role of institutional trust. Vaccine. 2023; 41: 2846-2852. [CrossRef]
  13. Al Shibli, A; Al Jufaili, M; Al Alawi, A; Balkhair, A; Al Zakwani, I; Al Azri, F; Al Maamari, K; Ba Alawi, F; Al Qayoudhi, A; Al Ghafri, H. Identification of Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Healthcare Workers at Sultan Qaboos University Hospital, Oman. Sultan Qaboos Univ Med J. 2023; 23:336-343. [CrossRef]
  14. Felemban, R. M.; Tashkandi, E. M.; Mohorjy, D. K. The willingness of the Saudi Arabian population to participate in the COVID-19 vaccine trial: A case–control study. J Taibah Univ Med Sci. 2021, 16, 612–618. [CrossRef]
  15. Kamacooko, O.; Kitonsa, J.; Bahemuka, U. M.; Kibengo, F. M.; Wajja, A.; Basajja, V.; Lumala, A.; Kakande, A.; Kafeero, P.; Ssemwanga, E.; Asaba, R.; Mugisha, J.; Pierce, B. F.; Shattock, R. J.; Kaleebu, P.; Ruzagira, E. Knowledge, Attitudes, and Practices Regarding COVID-19 among Healthcare Workers in Uganda: A Cross-Sectional Survey. Internatl J Environ Research Public Health 2021, 18 (13), 7004. [CrossRef]
  16. Atibioke, O. P.; Adepoju-Olajuwon, F.; Ojomo, O. A.; Oladeji, A. O.; Oripeloye, O. B.; Osinowo, K. A.; Ajuwon, A. J.; Ladipo, O. A. Knowledge, attitude and adherence to COVID-19 prevention among community health workers in Nigeria. Pan African Medical Journal 2022, 42. [CrossRef]
  17. Dereje, N.; Tesfaye, A.; Tamene, B.; Alemeshet, D.; Abe, H.; Tesfa, N.; Gideon, S.; Biruk, T.; Lakew, Y. COVID-19 vaccine hesitancy in Addis Ababa, Ethiopia: a mixed-method study. BMJ Open 2022, 12 (5), e052432. [CrossRef]
  18. Awuni, J. A.; Ayamga, M.; Dagunga, G. Covid-19 vaccination intensions among literate Ghanaians: Still the need to dissipate fear and build trust on vaccine efficacy? PLoS ONE 2022, 17 (6), e0270742.
  19. Ahiakpa, J. K.; Cosmas, N. T.; Anyiam, F. E.; Enalume, K. O.; Lawan, I.; Gabriel, I. B.; Oforka, C. L.; Dahir, H. G.; Fausat, S. T.; Nwobodo, M. A.; Massawe, G. P.; Obagha, A. S.; Okeh, D. U.; Karikari, B.; Aderonke, S. T.; Awoyemi, O. M.; Aneyo, I. A.; Doherty, F. V. COVID-19 vaccines uptake: Public knowledge, awareness, perception and acceptance among adult Africans. PLoS ONE 2022, 17 (6), e0268230. [CrossRef]
  20. Tolossa, T.; Wakuma, B.; Turi, E.; Mulisa, D.; Ayala, D.; Fetensa, G.; Mengist, B.; Abera, G.; Atomssa, E. M.; Seyoum, D.; Shibiru, T.; Getahun, A. Attitude of health professionals towards COVID-19 vaccination and associated factors among health professionals, Western Ethiopia: A cross-sectional survey. PLoS ONE 2022, 17 (3), e0265061. [CrossRef]
  21. Imediegwu, K. U.; Abor, J. C.; Onyebuchukwu, C. Q.; Ugwu, H. I.; Ugwu, O. I.; Anyaehie, U. E.; Onyia, O. A. Knowledge and acceptance of COVID-19 vaccine among healthcare workers in Enugu metropolis, Enugu state, Nigeria. Frontiers in Public Health 2023, 11. [CrossRef]
  22. Sialubanje, C.; Mukumbuta, N.; Ng’andu, M.; Sumani, E. M.; Nkonkomalimba, M.; Lyatumba, D. E.; Mwale, A.; Mpiana, F.; Zulu, J. M.; Mweempwa, B.; Endres, D.; Mbolela, M.; Namumba, M.; Peters, W.-C. Perspectives on the COVID-19 vaccine uptake: a qualitative study of community members and health workers in Zambia. BMJ Open 2022, 12 (11), e058028. [CrossRef]
  23. Mose, A.; Wasie, A.; Shitu, S.; Haile, K.; Timerga, A.; Melis, T.; Sahle, T.; Zewdie, A. Determinants of COVID-19 vaccine acceptance in Ethiopia: A systematic review and meta-analysis. PLoS ONE 2022, 17 (6), e0269273. [CrossRef]
  24. Miner, C. A.; Timothy, C. G.; Percy, K.; Mashige; Osuagwu, U. L.; Envuladu, E. A.; Amiebenomo, O. M.-A.; Ovenseri-Ogbomo, G.; Charwe, D. D.; Goson, P. C.; Ekpenyong, B. N.; Abu, E. K.; Langsi, R.; Oloruntoba, R.; Ishaya, T.; Agho, K. E. Acceptance of COVID-19 vaccine among sub-Saharan Africans (SSA): a comparative study of residents and diasporan dwellers. BMC Public Health 2023, 23. [CrossRef]
Table 1. Characteristics of the study population.
Table 1. Characteristics of the study population.
Variables Number %
Age Group
13-19, Youth 175 18
20-49, Early adult 678 68
50-64, Middle-aged adult 110 11
65-99, Older adult 37 3.7
Gender
Female 568 57
Male 432 43
Education Status
Primary school 92 9.2
Secondary school 312 31
College/University 505 50
Vocational/Technical 91 9.1
Living Status
Congregation 224 22
Single/Alone 304 30
Spouse or Small family 472 47
Job Status
Full-time work 316 32
Part-time work 168 17
Unemployed because or since COVID 180 18
Unemployed before COVID 336 34
Job Type
Business owner or executive 106 11
Essential worker, not healthcare 78 7.8
Healthcare worker 116 12
Labour worker 121 12
Market or store worker 83 8.3
Table 2. Knowledge of the population about COVID-19 disease transmission and control.
Table 2. Knowledge of the population about COVID-19 disease transmission and control.
Characteristics Number %
Cause of COVID-19
Bacteria 39 3.9
Virus 961 96
Route of transmission
Insects 32 3.2
Cough, sneeze 939 94
Household items 273 27
Close physical contact 499 50
Curse, bad luck 12 1.2
Treatment cure
Herbalist or spiritual cure 42 4.2
Antibiotic 117 12
Vaccine cure 418 42
Home remedy or mixture 108 11
Dexamethasone 36 3.6
No Cure 352 35
COVID is a problem
Covid is a problem 811 81
Covid is not a problem 119 19
Population affected
Affect poor people 98 9.8
Affect rich people 89 8.9
Affect rural people 72 7.2
Affect city people 61 6.1
Affect anyone 869 87
Preventive measures
Facemask 716 72
Hand hygiene 614 61
Physical distance 565 56
Vaccine 531 53
Medicine or Herb 68 6.8
No prevention 60 6.0
Responsibility for control
Government control 678 68
Private sector 319 32
Religious group 325 32
WHO control 518 52
Other charities or donors 191 19
Table 3. Knowledge of the COVID-19 vaccine types.
Table 3. Knowledge of the COVID-19 vaccine types.
Characteristics Number %
Awareness about the type of vaccines
AstraZeneca 748 75
Pfizer-Biontech 200 20
Sinovac 107 11
Covishield 112 11
Sputnik-Gamaleya 143 14
Moderna 90 9.0
Sinopharm 46 4.6
Janssen-Johnson 250 25
No vaccine awareness 124 12
Vaccine doses received
Vaccine 1st dose received 213 21
Vaccine 2nd dose received 44 4.4
Vaccine preferred
AstraZeneca 450 45
Covishield 89 8.9
Janssen-Johnson 275 28
Moderna 115 12
Pfizer-Biontech 71 7.1
Reasons of preference
Safety 404 40
Efficacy 956 96
Recommended by doctor 107 11
Readily available 195 19.5
No choice 226 23
Recommend by government or employer 241 24
Characteristics of vaccines
Vaccine safe 557 56
Vaccine secret ingredient 148 15
Vaccine tested well 397 40
Vaccine cause Covid 166 17
Vaccine minor effect 408 41
Vaccine death 262 26
Vaccines beneficial for the population
Vaccines good for old people 631 63
Good for young people 358 36
Good for healthcare worker 592 59
Good for chronic disease 440 44
Good for international travelers 425 42
Good for rich 266 27
Table 4. Association between sociodemographic factors and knowledge level COVID-19 disease.
Table 4. Association between sociodemographic factors and knowledge level COVID-19 disease.
Characteristics Poor knowledge Good knowledge p-value
Number
N = 430
% Number
N = 570
%
Age group 0.3
13-19, Youth 78 45 97 55
20-49, Early adult 297 44 381 56
50-64, Middle-aged 38 35 72 65
65-99, Older adult 17 46 20 54
Gender 0.7
Female 247 43 321 57
Male 183 42 249 58
Education Status 0.001
Primary school 41 45 51 55
Secondary school 126 40 186 60
College/University 206 41 299 59
Vocational/Technical 57 63 34 37
Living Status 0.001
Congregation 112 50 112 50
Single/alone 143 47 161 53
Spouse/small family 175 37 297 63
Job Status 0.002
Full-time work 114 36 202 64
Part-time work 69 41 99 59
Unemployed because or since COVID 76 42 104 58
Unemployed before COVID 171 51 165 49
Job Type <0.001
Business owner or executive 32 30 74 70
Essential worker, not healthcare 28 36 50 64
Healthcare worker 71 61 45 39
Labour work 47 39 74 61
Market or store worker 35 42.2 48 57.8
Office worker 78 42 108 58
Student 139 45 171 55
Table 5. Logistic regression of factors associated with poor knowledge about COVID-19 disease.
Table 5. Logistic regression of factors associated with poor knowledge about COVID-19 disease.
Characteristic OR1 95% CI1 p-value
Education Status
Primary
Secondary 0.80 0.49 - 1.32 0.4
College/University 0.65 0.39 - 1.08 0.093
Vocational/Technical 2.20 1.16 - 4.23 0.017
Living Status
Congregation
Single/alone 1.22 0.84 - 1.77 0.3
Spouse/small family 0.83 0.58 - 1.18 0.3
Job Status
Full-time work
Part-time work 1.57 0.99 - 2.49 0.057
Unemployed because or since COVID 2.03 1.30 - 3.19 0.002
Unemployed before COVID 3.37 2.17 - 5.29 <0.001
Job Type
Business owner or Executive
Essential worker, not healthcare 1.22 0.61 - 2.43 0.6
Healthcare worker 6.08 3.20 - 11.8 <0.001
Labour work 1.02 0.57 - 1.85 >0.9
Market or store worker 1.36 0.68 - 2.71 0.4
Office worker 1.56 0.91 - 2.71 0.11
Student 0.98 0.57 - 1.70 >0.9
1 OR = Odds Ratio, CI = Confidence Interval.
Table 6. Association between sociodemographic factors and attitude toward COVID-19 vaccine.
Table 6. Association between sociodemographic factors and attitude toward COVID-19 vaccine.
Characteristic Poor Attitude Good attitude p-value
N = 817 % N = 183 %
Age Group <0.001
13-19, Youth 164 94 11 6.3
20-49, Early adult 546 81 132 19
50-64, Middle-aged 82 75 28 25
65-99, Older adult 25 68 12 32
Gender 0.3
Female 471 83 97 17
Male 346 80 86 20
Education Status <0.001
Primary 83 100 9 9.9
Secondary 259 83 53 17
College/University 391 77 114 23
Vocational/Technical 84 92 7 7.7
Living Status <0.001
Congregation 214 96 10 4.5
Single/alone 253 83 51 17
Spouse/small family 350 74 122 26
Job Status <0.001
Full-time work 224 71 92 29
Part-time work 143 85 25 15
Unemployed because or since COVID 159 88 21 12
Unemployed before COVID 291 87 45 13
Job Type 0.1
Business owner or executive 85 80 21 20
Essential worker, not healthcare 69 88 9 12
Healthcare worker 91 78 25 22
Labour work 99 82 22 18
Market or store worker 63 75.9 20 24
Office worker 142 76 44 24
Student 268 86 42 14
Table 7. Logistic regression of factors associated with poor attitude toward COVID-19 disease.
Table 7. Logistic regression of factors associated with poor attitude toward COVID-19 disease.
Characteristic OR1 95% CI1 p-value
Age Group
13-19, Youth
20-49, Early adult 0.26 0.12, 0.56 <0.001
50-64, Middle-aged 0.22 0.08, 0.56 0.002
65-99, Older adult 0.12 0.04, 0.37 <0.001
Education Status
Primary school 12,303 0.00, NA >0.9
Secondary school 0.56 0.23, 1.23 0.2
College/University 0.48 0.20, 1.06 0.083
Vocational/Technical 1.23 0.40, 3.94 0.7
Living Status
Congregation
Single/alone 0.36 0.17, 0.72 0.006
Spouse/small family 0.17 0.08, 0.33 <0.001
Job Status
Full-time work
Part-time work 1.68 0.96, 3.00 0.075
Unemployed because or since COVID 2.89 1.61, 5.33 <0.001
Unemployed before COVID 2.04 1.18, 3.55 0.011
Job Type
Business owner or executive
Essential worker, not healthcare 2.02 0.81, 5.37 0.14
Healthcare worker 0.92 0.41, 2.07 0.8
Labour worker 0.70 0.33, 1.48 0.4
Market or store worker 0.56 0.24, 1.30 0.2
Office worker 0.68 0.35, 1.31 0.3
Student 0.47 0.22, 0.99 0.049
1 OR = Odds Ratio, CI = Confidence Interval.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
Prerpints.org logo

Preprints.org is a free preprint server supported by MDPI in Basel, Switzerland.

Subscribe

Disclaimer

Terms of Use

Privacy Policy

Privacy Settings

© 2025 MDPI (Basel, Switzerland) unless otherwise stated