Submitted:
08 September 2024
Posted:
09 September 2024
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Abstract
Keywords:
1. Introduction
2. Literature Review and Analysis
3. Learning goal Orientation
4. Growth Mindset
5. Organisational Learning
6. Materials and Methods

7. Results
| Question | Expert Rating | Calculated Values | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Dimension | 1 | 2 | 3 | 4 | 5 | 6 | 7 | Mean* | CVI | |
| 1 | Mindset | 1 | 2 | 3 | 2 | 1 | 5,00 | 0,67 | ||
| 2 | Mindset | 1 | 1 | 7 | 5,56 | 0,89 | ||||
| 3 | Mindset | 1 | 1 | 3 | 4 | 5,89 | 0,89 | |||
| 4 | Mindset | 2 | 3 | 4 | 6,22 | 1,00 | ||||
| 5 | Mindset | 1 | 1 | 7 | 6,56 | 0,89 | ||||
| 6 | Mindset | 2 | 1 | 1 | 2 | 3 | 5,00 | 0,67 | ||
| 7 | Behaviour | 1 | 2 | 6 | 5,56 | 0,89 | ||||
| 8 | Behaviour | 2 | 1 | 2 | 1 | 3 | 5,00 | 0,67 | ||
| 9 | Behaviour | 1 | 4 | 4 | 6,22 | 0,89 | ||||
| 10 | Behaviour | 2 | 1 | 3 | 2 | 1 | 4,89 | 0,67 | ||
| 11 | Behaviour | 1 | 2 | 4 | 2 | 5,67 | 0,89 | |||
| 12 | Behaviour | 2 | 4 | 3 | 6,11 | 1,00 | ||||
| 13 | Behaviour | 1 | 1 | 4 | 3 | 5,89 | 0,89 | |||
| 14 | Behaviour | 1 | 2 | 1 | 2 | 3 | 4,78 | 0,67 | ||
| 15 | Improvement | 3 | 1 | 3 | 2 | 5,44 | 0,67 | |||
| 16 | Improvement | 1 | 5 | 3 | 6,00 | 0,89 | ||||
| 17 | Improvement | 1 | 2 | 3 | 3 | 5,67 | 0,89 | |||
| 18 | Improvement | 2 | 5 | 2 | 6,00 | 1,00 | ||||
| 19 | Improvement | 1 | 7 | 1 | 5,78 | 0,89 | ||||
8. Discussion
9. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
- Open mindset to explore new things.
- Question habits and routines.
- Continuous improvement of own competences.
| Item | Question | Source |
|---|---|---|
| Mindset | I would never stop learning as there is a risk of not keeping up to date and missing out on opportunities. | [60] |
| Mindset | New experiences with digital technologies or tools are learning opportunities for me. | [61] |
| Mindset | I regularly join or listen to conversations and discussions about new technologies. | [62] |
| Mindset | I can derive new ideas from things I have learned. | [63] |
| Mindset | If there are new technologies or tools, which make things easier for me, I want to know more about it. | New |
| Mindset | I incorporate feedback to make changes in my behaviour | [64] |
| Behaviour | I am interested in new topics, try to interact, and informed myself about occurring new technologies. | [63,65,66] |
| Behaviour | I value original ideas and constant innovation. | [67] |
| Behaviour | I am watching explanation videos (e.g., on youtube or other platforms) and / or read additional instructions to improve my knowledge. | [65] |
| Behaviour | I am not afraid to critically reflect my underlying assumptions. | [62,67] |
| Behaviour | If I learn something new about digital technologies, I think about how I could transfer this into my daily routines. | [65] |
| Behaviour | If I learn something new about digital technologies, I rethink how I did things before and try to make it better based on my new knowledge. | [65] |
| Behaviour | I continuously judge my decisions and activities towards using digital technologies. | [62] |
| Behaviour | One of my basic values is to include learning as a key to improvement. | [67] |
| Improvement | I try to integrate digital technologies, even if I need to think about doing things in a different way I did before. | [61,65] |
| Improvement | I view the ability to learn as the key to improvement. | [60] |
| Improvement | I long for learning to improve myself. | [60] |
| Improvement | I perceive learning as investment, not an expense. | [60] |
| Improvement | I can transfer the knowledge I already have to adapt other similar technology | [66] |
Appendix B
- Individual attitude: Open mindset to explore new things - Accept.
- Behavioural pattern: Questioning habits and routines – Act and Reflect.
- Outcome: Continuous improvement of competences – Implementation and learning loops.
| Item | Question |
|---|---|
| Mindset | If there are conversations and discussions about new technologies in my environment, I am interested in them. |
| Mindset | If someone tells me about new ideas to use technology, I am open to them |
| Mindset | If there are new technologies or tools that make my work easier, I want to know more about it. |
| Behaviour | I watch explanation videos (e.g., on youtube or other platforms) and/or read additional instructions to improve my knowledge. |
| Behaviour | When I learn something new about digital technologies, I rethink my previous actions and try to develop them further with the new knowledge. |
| Behaviour | If situations are changing, I adapt my decisions and activities regarding the use of digital technologies. |
| Improvement | I acquire new knowledge and skills independently. |
| Improvement | I am willing to invest time and money to integrate new technologies or processes in my daily live. |
| Improvement | The knowledge I already have helps me to use other technologies |
References
- Kraus, S.; Schiavone, F.; Pluzhnikova, A.; Invernizzi, A. C. Digital Transformation in Healthcare: Analyzing the Current State-of-Research. J Bus Res, 2021, 123, 557–567. [Google Scholar] [CrossRef]
- Laurenza, E.; Quintano, M.; Schiavone, F.; Vrontis, D. The Effect of Digital Technologies Adoption in Healthcare Industry: A Case Based Analysis. Business Process Management Journal, 2018, 24, 1124–1144. [Google Scholar] [CrossRef]
- Tortorella, G. L.; Fogliatto, F. S.; Mac Cawley Vergara, A.; Vassolo, R.; Sawhney, R. Healthcare 4.0: Trends, Challenges and Research Directions. Production Planning and Control, 2020, 31, 1245–1260. [Google Scholar] [CrossRef]
- Rupeika-Apoga, R.; Petrovska, K. Barriers to Sustainable Digital Transformation in Micro-, Small-, and Medium-Sized Enterprises. Sustainability, 2022, 14, 13558. [Google Scholar] [CrossRef]
- D’Onofrio, S. Der Digitale Wandel Im Gesundheitswesen. HMD Praxis der Wirtschaftsinformatik, 2022, 59, 1448–1460. [Google Scholar] [CrossRef]
- Jones, G. L.; Peter, Z.; Rutter, K.-A.; Somauroo, A. Promoting an Overdue Digital Transformation in Healthcare. Ariel 2019. [Google Scholar]
- Iyanna, S.; Kaur, P.; Ractham, P.; Talwar, S.; Najmul Islam, A. K. M. Digital Transformation of Healthcare Sector. What Is Impeding Adoption and Continued Usage of Technology-Driven Innovations by End-Users? J Bus Res, 2022, 153, 150–161. [Google Scholar] [CrossRef]
- Ivaldi, S.; Scaratti, G.; Fregnan, E. Dwelling within the Fourth Industrial Revolution: Organizational Learning for New Competences, Processes and Work Cultures. Journal of Workplace Learning, 2022, 34, 1–26. [Google Scholar] [CrossRef]
- Melhem, S., J. A. H. A Global Study on Digital Capabilities; 2021.
- Albort-Morant, G.; Leal-Rodríguez, A. L.; Fernández-Rodríguez, V.; Ariza-Montes, A. Assessing the Origins, Evolution and Prospects of the Literature on Dynamic Capabilities: A Bibliometric Analysis. European Research on Management and Business Economics, 2018, 24, 42–52. [Google Scholar] [CrossRef]
- Easterby-Smith, M.; Prieto, I. M. Dynamic Capabilities and Knowledge Management: An Integrative Role for Learning? British Journal of Management, 2008, 19, 235–249. [Google Scholar] [CrossRef]
- Yáñez-Araque, B.; Moreno-Garcia, J.; Hernández-Perlines, F. Editorial: Training, Performance, and Dynamic Capabilities: New Insights from Absorptive, Innovative, Adaptative, and Learning Capacities. Front Psychol, 2023, 14. [Google Scholar] [CrossRef] [PubMed]
- Augier, M.; Teece, D. J. Understanding Complex Organization: The Role of Know-How, Internal Structure, and Human Behavior in the Evolution of Capabilities. Industrial and Corporate Change, 2006, 15, 395–416. [Google Scholar] [CrossRef]
- Mahoney, J. T. The Management of Resources and the Resource of Management. J Bus Res, 1995, 33, 91–101. [Google Scholar] [CrossRef]
- Zollo, M.; Winter, S. G. Deliberate Learning and the Evolution of Dynamic Capabilities. Organization science, 2002, 13, 339–351. [Google Scholar] [CrossRef]
- Crossan, M. M.; Lane, H. W.; White, R. E. An Organizational Learning Framework: From Intuition to Institution. Academy of management review, 1999, 24, 522–537. [Google Scholar] [CrossRef]
- Loureiro, R.; Ferreira, J. J.; Simões, J. Understanding Healthcare Sector Organizations from a Dynamic Capabilities Perspective. European Journal of Innovation Management, 2023, 26, 588–614. [Google Scholar] [CrossRef]
- Pablo, A. L.; Reay, T.; Dewald, J. R.; Casebeer, A. L. Identifying, Enabling and Managing Dynamic Capabilities in the Public Sector*. Journal of Management Studies, 2007, 44, 687–708. [Google Scholar] [CrossRef]
- Belliger, A.; Krieger, D. J. The Digital Transformation of Healthcare. Knowledge management in digital change: New findings and practical cases, 2018; 311–326. [Google Scholar] [CrossRef]
- Goldin, C.; Katz, L. F. The Race between Education and Technology; harvard university press, 2009.
- Teece, D. J.; Pisano, G.; Shuen, A. Dynamic Capabilities and Strategic Management. Strategic Management Journal, 1997, 18, 509–533. [Google Scholar] [CrossRef]
- Arndt, F.; Bach, N. Evolutionary and Ecological Conceptualization of Dynamic Capabilities: Identifying Elements of the Teece and Eisenhardt Schools. Journal of Management & Organization, 2015, 21, 701–704. [Google Scholar] [CrossRef]
- Eisenhardt, K. M.; Martin, J. A. Dynamic Capabilities: What Are They? Strategic management journal, 2000, 21, (10–11). [Google Scholar] [CrossRef]
- Barreto, I. Dynamic Capabilities: A Review of Past Research and an Agenda for the Future. J Manage, 2010, 36, 256–280. [Google Scholar] [CrossRef]
- Agarwal, R.; Selen, W. The Incremental and Cumulative Effects of Dynamic Capability Building on Service Innovation in Collaborative Service Organizations. Journal of Management & Organization, 2013, 19, 521–543. [Google Scholar]
- Warner, K. S. R.; Wäger, M. Building Dynamic Capabilities for Digital Transformation: An Ongoing Process of Strategic Renewal. Long Range Plann, 2019, 52, 326–349. [Google Scholar] [CrossRef]
- Ellström, D.; Holtström, J.; Berg, E.; Josefsson, C. Dynamic Capabilities for Digital Transformation. Journal of Strategy and Management, 2022, 15, 272–286. [Google Scholar] [CrossRef]
- Berman, T.; Schallmo, D.; Kraus, S. Strategies for Digital Entrepreneurship Success: The Role of Digital Implementation and Dynamic Capabilities. European Journal of Innovation Management, 2024, 27, 198–222. [Google Scholar] [CrossRef]
- Vandewalle, D. Development and Validation of a Work Domain Goal Orientation Instrument. Educ Psychol Meas, 1997, 57, 995–1015. [Google Scholar] [CrossRef]
- Dweck, C. S.; Yeager, D. S. Mindsets: A View From Two Eras. Perspectives on Psychological Science, 2019, 14, 481–496. [Google Scholar] [CrossRef]
- Dweck, C. Mindset-Updated Edition: Changing the Way You Think to Fulfil Your Potential; Hachette UK, 2017.
- Rhew, E.; Piro, J. S.; Goolkasian, P.; Cosentino, P. The Effects of a Growth Mindset on Self-Efficacy and Motivation. Cogent Education, 2018, 5. [Google Scholar] [CrossRef]
- Crossan, M. M.; Lane, H. W.; White, R. E.; Djurfeldt, L. ORGANIZATIONAL LEARNING: DIMENSIONS FOR A THEORY. The International Journal of Organizational Analysis, 1995, 3, 337–360. [Google Scholar] [CrossRef]
- Easterby-Smith, M.; Crossan, M.; Nicolini, D. Organizational Learning: Debates Past, Present And Future. Journal of Management Studies, 2000, 37, 783–796. [Google Scholar] [CrossRef]
- Straub, D. W. Validating Instruments in MIS Research. MIS quarterly, 1989; 147–169. [Google Scholar]
- Tsang, S.; Royse, C.; Terkawi, A. Guidelines for Developing, Translating, and Validating a Questionnaire in Perioperative and Pain Medicine. Saudi J Anaesth, 2017, 11. [Google Scholar] [CrossRef] [PubMed]
- Mergel, I.; Edelmann, N.; Haug, N. Defining Digital Transformation: Results from Expert Interviews. Gov Inf Q, 2019, 36. [Google Scholar] [CrossRef]
- Meuser, M.; Nagel, U. Expertlnneninterviews—Vielfach Erprobt, Wenig Bedacht: Ein Beitrag Zur Qualitativen Methodendiskussion; Springer, 1991.
- Colquitt, J. A.; Sabey, T. B.; Rodell, J. B.; Hill, E. T. Content Validation Guidelines: Evaluation Criteria for Definitional Correspondence and Definitional Distinctiveness. Journal of Applied Psychology, 2019, 104, 1243–1265. [Google Scholar] [CrossRef] [PubMed]
- Miller, V. A.; Reynolds, W. W.; Ittenbach, R. F.; Luce, M. F.; Beauchamp, T. L.; Nelson, R. M. Challenges in Measuring a New Construct: Perception of Voluntariness for Research and Treatment Decision Making. Journal of Empirical Research on Human Research Ethics, 2009, 4, 21–31. [Google Scholar] [CrossRef]
- Sireci, S. G.; Faulkner-Bond, M. Validity Evidence Based on Test Content. Psicothema, 2014. [Google Scholar]
- Polit, D. F.; Beck, C. T.; Owen, S. V. Is the CVI an Acceptable Indicator of Content Validity? Appraisal and Recommendations. Res Nurs Health, 2007, 30, 459–467. [Google Scholar] [CrossRef]
- Paisant, A.; Skehan, S.; Colombié, M.; David, A.; Aubé, C. Development and Validation of Core Entrustable Professional Activities for Abdominal Radiology. Insights Imaging, 2023, 14, 142. [Google Scholar] [CrossRef]
- Schmitz, K.; Storey, V. C. Empirical Test Guidelines for Content Validity: Wash, Rinse, and Repeat until Clean. Communications of the Association for Information Systems, 2020, 47, 64. [Google Scholar] [CrossRef]
- Teece, D. J. Explicating Dynamic Capabilities: The Nature and Microfoundations of (Sustainable) Enterprise Performance. Strategic Management Journal, 2007, 28, 1319–1350. [Google Scholar] [CrossRef]
- Eisenhardt, K. M. Building Theories from Case Study Research. Academy of Management Review, 1989, 14, 532–550. [Google Scholar] [CrossRef]
- Almanasreh, E.; Moles, R.; Chen, T. F. Evaluation of Methods Used for Estimating Content Validity. Research in Social and Administrative Pharmacy, 2019, 15, 214–221. [Google Scholar] [CrossRef]
- Hinkin, T. R.; Tracey, J. B. An Analysis of Variance Approach to Content Validation. Organ Res Methods, 1999, 2, 175–186. [Google Scholar] [CrossRef]
- Hu, L.; Bentler, P. M. Cutoff Criteria for Fit Indexes in Covariance Structure Analysis: Conventional Criteria versus New Alternatives. Struct Equ Modeling, 1999, 6, 1–55. [Google Scholar] [CrossRef]
- Schermelleh-Engel, K.; Moosbrugger, H.; Müller, H. Evaluating the Fit of Structural Equation Models: Tests of Significance and Descriptive Goodness-of-Fit Measures. Methods of psychological research online, 2003, 8, 23–74. [Google Scholar]
- Al-Hail, M.; Zguir, M. F.; Koç, M. Exploring Digital Learning Opportunities and Challenges in Higher Education Institutes: Stakeholder Analysis on the Use of Social Media for Effective Sustainability of Learning–Teaching–Assessment in a University Setting in Qatar. Sustainability, 2024, 16, 6413. [Google Scholar] [CrossRef]
- Demir, K. Future of Undergraduate Education for Sustainable Development Goals: Impact of Perceived Flexibility and Attitudes on Self-Regulated Online Learning. Sustainability, 2024, 16, 6444. [Google Scholar] [CrossRef]
- Winter, S. G. Understanding Dynamic Capabilities. Strategic Management Journal, 2003, 24, 991–995. [Google Scholar] [CrossRef]
- Arndt, F. Dynamic Capabilities: A Retrospective, State-of-the-Art, and Future Research Agenda. Journal of Management & Organization. [CrossRef]
- Dougherty, D.; Barnard, H.; Dunne, D. Exploring the Everyday Dynamics of Dynamic Capabilities; 3rd Annual MIT/UCI Knowledge and Organizations Conference, Laguna Beach, CA, 2004.
- Dörner, O.; Rundel, S. Organizational Learning and Digital Transformation: A Theoretical Framework. In Digital Transformation of Learning Organizations; Springer International Publishing: Cham, 2021; pp. 61–75. [Google Scholar] [CrossRef]
- Colli, M.; Stingl, V.; Waehrens, B. V. Making or Breaking the Business Case of Digital Transformation Initiatives: The Key Role of Learnings. Journal of Manufacturing Technology Management, 2022, 33, 41–60. [Google Scholar] [CrossRef]
- Gardner, N. Digital Transformation and Organizational Learning: Situated Perspectives on Becoming Digital in Architectural Design Practice. Front Built Environ, 2022, 8. [Google Scholar] [CrossRef]
- Gupta, G.; Bose, I. Strategic Learning for Digital Market Pioneering: Examining the Transformation of Wishberry’s Crowdfunding Model. Technol Forecast Soc Change, 2019, 146, 865–876. [Google Scholar] [CrossRef]
- Awan, U.; Braathen, P.; Hannola, L. When and How the Implementation of Green Human Resource Management and Data-driven Culture to Improve the Firm Sustainable Environmental Development? Sustainable Development, 2023, 31, 2726–2740. [Google Scholar] [CrossRef]
- Kim, H.; Hong, A.; Song, H.-D. The Relationships of Family, Perceived Digital Competence and Attitude, and Learning Agility in Sustainable Student Engagement in Higher Education. Sustainability, 2018, 10. [Google Scholar] [CrossRef]
- Feng, T.; Zhao, G.; Su, K. The Fit between Environmental Management Systems and Organisational Learning Orientation. Int J Prod Res, 2014, 52, 2901–2914. [Google Scholar] [CrossRef]
- Lee, J.; Song, H.-D.; Hong, A. Exploring Factors, and Indicators for Measuring Students’ Sustainable Engagement in e-Learning. Sustainability, 2019, 11. [Google Scholar] [CrossRef]
- Tjin A Tsoi, S. L. N. M.; de Boer, A.; Croiset, G.; Koster, A. S.; van der Burgt, S.; Kusurkar, R. A. How Basic Psychological Needs and Motivation Affect Vitality and Lifelong Learning Adaptability of Pharmacists: A Structural Equation Model. Advances in Health Sciences Education, 2018, 23, 549–566. [Google Scholar] [CrossRef] [PubMed]
- Forbes, D.; Gedera, D.; Hartnett, M.; Datt, A.; Brown, C. Sustainable Strategies for Teaching and Learning Online. Sustainability, 2023, 15, 13118. [Google Scholar] [CrossRef]
- Karamitri, I.; Kitsios, F.; Talias, M. A. Development and Validation of a Knowledge Management Questionnaire for Hospitals and Other Healthcare Organizations. Sustainability, 2020, 12, 2730. [Google Scholar] [CrossRef]
- Baker, W. E.; Sinkula, J. M. The Synergistic Effect of Market Orientation and Learning Orientation on Organizational Performance. J Acad Mark Sci, 1999, 27, 411–427. [Google Scholar] [CrossRef]

| Expert | Country | Expertise |
| 1 | USA | University (Professor): knowledge management, motivation |
| 2 | Germany | University (Professor): digital management, innovation management |
| 3 | Latvia | University (PhD, Lecturer): employee engagement and motivation, HR |
| 4 | Germany | University (Assistant Professor): innovation, digital learning |
| 5 | Germany | Freelancer (PhD): education, German translation |
| 6 | Germany | Healthcare (Division management): HR development, digital competences |
| 7 | Germany | University (Professor): social sciences, employability skills |
| 8 | Germany | Healthcare (Department management): design thinking, innovation |
| 9 | Germany | University (Researcher): future skills, education and lifelong learning |
| Dimension | 1 | 2 | 3 | 4 | 5 | 6 | 7 | Mean* | CVI | HTC |
|---|---|---|---|---|---|---|---|---|---|---|
| Mindset | 1 | 1 | 3 | 4 | 5,89 | 0,89 | 0,84 | |||
| Mindset | 2 | 3 | 4 | 6,22 | 1,00 | 0,89 | ||||
| Mindset | 1 | 1 | 7 | 6,56 | 0,89 | 0,94 | ||||
| Behaviour | 1 | 4 | 4 | 6,22 | 0,89 | 0,89 | ||||
| Behaviour | 2 | 4 | 3 | 6,11 | 1,00 | 0,87 | ||||
| Behaviour | 1 | 1 | 4 | 3 | 5,89 | 0,89 | 0,84 | |||
| Improvement | 1 | 5 | 3 | 6,00 | 0,89 | 0,86 | ||||
| Improvement | 2 | 5 | 2 | 6,00 | 1,00 | 0,86 | ||||
| Improvement | 1 | 7 | 1 | 5,78 | 0,89 | 0,83 | ||||
| Average | 0.93 | 0.87 |
| Dimension | Sustained learning* | Learning goal orientation* | Growth mindset* | Organisational learning* | |
| 1 | Mindset | 5,51** | 5,14 | 4,61 | 5,09 |
| 2 | Mindset | 5,47** | 5,32 | 4,93 | 5,11 |
| 3 | Mindset | 5,72** | 5,57 | 4,91 | 4,98 |
| 4 | Behaviour | 5,48 | 5,77** | 4,96 | 4,30 |
| 5 | Behaviour | 5,71** | 5,36 | 5,54 | 4,51 |
| 6 | Behaviour | 5,34 | 5,21 | 5,40** | 4,71 |
| 7 | Improvement | 5,48 | 5,74** | 4,88 | 4,27 |
| 8 | Improvement | 5,13 | 5,31** | 4,59 | 4,30 |
| 9 | Improvement | 4,46 | 4,47** | 4,42 | 4,05 |
| Fit measure | Result | Acceptable fit | Good fit |
|---|---|---|---|
| x2 | 34.2 | 2df<x2 ≤ 3df | 0 ≤ x2 ≤ 2df0 ≤ 34.2 ≤ 38 |
| p | 0.018 | 0.01 ≤ p ≤ 0.050.01 ≤ 0.018 ≤ 0.05 | 0.05<p ≤ 1.00 |
| df | 19 | ||
| x2/df | 1.8 | 2<x2/df ≤ 3 | 0 ≤ x2/df ≤ 20 ≤ 1.8 ≤ 2 |
| Subdimension | Survey Item |
|---|---|
| Individual attitude: Open mindset to explore new things - Accept. | If there are conversations and discussions about new technologies in my environment, I am interested in them. |
| If someone tells me about new ideas to use technology, I am open to them | |
| If there are new technologies or tools that make my work easier, I want to know more about it. | |
| Behavioural pattern: Questioning habits and routines – Act and Reflect. | I watch explanation videos (e.g., on youtube or other platforms) and/or read additional instructions to improve my knowledge. |
| When I learn something new about digital technologies, I rethink my previous actions and try to develop them further with the new knowledge. | |
| If situations are changing, I adapt my decisions and activities regarding the use of digital technologies. |
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