Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis

Fabiana Furci; Marco Umberto Scaramozzino; Giuseppe Rocco Talesa; Giusi Gisella Crea; Corrado Pelaia

doi:10.20944/preprints202408.0228.v1

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preprints.org > public health and healthcare > public health and health services > doi: 10.20944/preprints202408.0228.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis

Fabiana Furci

Marco Umberto Scaramozzino

^* ,

Giuseppe Rocco Talesa

Giusi Gisella Crea

Corrado Pelaia

Version 1 : Received: 4 August 2024 / Approved: 4 August 2024 / Online: 6 August 2024 (06:09:10 CEST)

How to cite: Furci, F.; Scaramozzino, M. U.; Talesa, G. R.; Crea, G. G.; Pelaia, C. Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis. Preprints 2024, 2024080228. https://doi.org/10.20944/preprints202408.0228.v1 Furci, F.; Scaramozzino, M. U.; Talesa, G. R.; Crea, G. G.; Pelaia, C. Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis. Preprints 2024, 2024080228. https://doi.org/10.20944/preprints202408.0228.v1

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MDPI and ACS Style

Furci, F.; Scaramozzino, M. U.; Talesa, G. R.; Crea, G. G.; Pelaia, C. Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis. Preprints 2024, 2024080228. https://doi.org/10.20944/preprints202408.0228.v1

APA Style

Furci, F., Scaramozzino, M. U., Talesa, G. R., Crea, G. G., & Pelaia, C. (2024). Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis. Preprints. https://doi.org/10.20944/preprints202408.0228.v1

Chicago/Turabian Style

Furci, F., Giusi Gisella Crea and Corrado Pelaia. 2024 "Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis" Preprints. https://doi.org/10.20944/preprints202408.0228.v1

Abstract

Asthma is a chronic inflammatory disease for which the main anti-inflammatory drugs for better disease control are steroids or corticosteroids. The use of steroids in asthma patients, in particular in uncontrolled asthma patients, is associated with an increased risk of osteoporosis and fragility fractures. A single oral corticosteroids course increases the risk of osteoporosis and continual use of inhaled corticosteroids is correlated over time to an increased risk for both bone conditions. With the use of new, available biologic therapies for asthma, perhaps even anticipating the times of their use in what are the steps of therapeutic management, in the current guidelines and with targeted strategies of prevention it may be possible to improve asthma management, preventing some comorbidities, such as osteoporosis.

Keywords

severe asthma; biologics; corticosteroids; inflammation; interleukins; osteoporosis

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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