Version 1
: Received: 16 May 2024 / Approved: 17 May 2024 / Online: 17 May 2024 (12:49:37 CEST)
How to cite:
Gamba, A.; Zen, M.; Depascale, R.; Calligaro, A.; Gatto, M.; Iaccarino, L.; Doria, A. Modern Management of Pregnancy in Systemic Lupus Erythematosus: From Prenatal Counselling to Postpartum Support. Preprints2024, 2024051182. https://doi.org/10.20944/preprints202405.1182.v1
Gamba, A.; Zen, M.; Depascale, R.; Calligaro, A.; Gatto, M.; Iaccarino, L.; Doria, A. Modern Management of Pregnancy in Systemic Lupus Erythematosus: From Prenatal Counselling to Postpartum Support. Preprints 2024, 2024051182. https://doi.org/10.20944/preprints202405.1182.v1
Gamba, A.; Zen, M.; Depascale, R.; Calligaro, A.; Gatto, M.; Iaccarino, L.; Doria, A. Modern Management of Pregnancy in Systemic Lupus Erythematosus: From Prenatal Counselling to Postpartum Support. Preprints2024, 2024051182. https://doi.org/10.20944/preprints202405.1182.v1
APA Style
Gamba, A., Zen, M., Depascale, R., Calligaro, A., Gatto, M., Iaccarino, L., & Doria, A. (2024). Modern Management of Pregnancy in Systemic Lupus Erythematosus: From Prenatal Counselling to Postpartum Support. Preprints. https://doi.org/10.20944/preprints202405.1182.v1
Chicago/Turabian Style
Gamba, A., Luca Iaccarino and Andrea Doria. 2024 "Modern Management of Pregnancy in Systemic Lupus Erythematosus: From Prenatal Counselling to Postpartum Support" Preprints. https://doi.org/10.20944/preprints202405.1182.v1
Abstract
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that predominantly affects women in the childbearing age. Pregnancy in SLE patients poses unique challenges due to the po-tential impact on maternal and fetal outcomes. We provide an overview of the management of SLE during pregnancy, including pre-conception risk stratification and counselling, treatment, and disease activity monitoring. These assessments are critical to minimize maternal and fetal adverse events in SLE pregnant patients. Disease flares, preeclampsia, antiphospholipid syn-drome complications, and maternal mortality are the major risks for a woman with SLE during gestation. Timely treatment of SLE relapse, differentiation of preeclampsia from lupus nephritis, and tailored management for antiphospholipid syndrome are essential for a successful pregnan-cy. Fetal outcomes include neonatal lupus (NL), preterm birth, cesarean delivery, fetal growth re-striction (FGR), and small for gestational age (SGA) infants. We focused on NL, linked to mater-nal anti-Ro/SS-A and anti-La/SS-B antibodies, which can lead to various manifestations, partic-ularly cardiac abnormalities in newborns. While there is a common consensus regarding the pre-ventive effect of hydroxychloroquine, the role of echocardiographic monitoring and fluorinated steroid treatment is still debated. Finally, close postpartum monitoring and counseling for sub-sequent pregnancies are crucial aspects of care.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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