Hypothesis
Version 1
Preserved in Portico This version is not peer-reviewed
Ex Vivo Tissue-Resident Macrophage Replacement Prior to Allogeneic Transplantation
Version 1
: Received: 11 May 2024 / Approved: 13 May 2024 / Online: 13 May 2024 (16:25:55 CEST)
How to cite: Renteln, M. Ex Vivo Tissue-Resident Macrophage Replacement Prior to Allogeneic Transplantation. Preprints 2024, 2024050864. https://doi.org/10.20944/preprints202405.0864.v1 Renteln, M. Ex Vivo Tissue-Resident Macrophage Replacement Prior to Allogeneic Transplantation. Preprints 2024, 2024050864. https://doi.org/10.20944/preprints202405.0864.v1
Abstract
Organ shortage is one of the most pressing issues with regard to human mortality. This issue is further complicated by the fact that HLA matching is required for patients, leading to restricted choices for transplant. If organs or tissues from non- or partially-HLA–matched donors could be edited such they evade cytotoxic T cells as well as natural killer cells, it would ameliorate the organ shortage problem.
Keywords
normothermic machine perfusion; tissue-resident macrophage replacement; E. coli Nissle 1917; bactofection; CRISPR transposase; HLA-E
Subject
Medicine and Pharmacology, Transplantation
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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