Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

IL-6 Polymorphism as a Predisposing Genetic Factor for Gestational Diabetes or Preeclampsia Development in Pregnancy with Obesity: VEGF and VEGFF Receptor Related Gene Expression Modalities

Panagiotis Halvatsiotis
* ORCID logo ,
Theodora Tsokaki
,
Vassileios Tsitsis
,
Lina Palaiodimou
ORCID logo ,
Georgios Tsivgoulis
ORCID logo ,
Iraklis Tsangaris
ORCID logo ,
Ourania Panagiotou
,
Dimitra Houhoula
Version 1 : Received: 6 May 2024 / Approved: 7 May 2024 / Online: 7 May 2024 (10:19:41 CEST)

How to cite: Halvatsiotis, P.; Tsokaki, T.; Tsitsis, V.; Palaiodimou, L.; Tsivgoulis, G.; Tsangaris, I.; Panagiotou, O.; Houhoula, D. IL-6 Polymorphism as a Predisposing Genetic Factor for Gestational Diabetes or Preeclampsia Development in Pregnancy with Obesity: VEGF and VEGFF Receptor Related Gene Expression Modalities. Preprints 2024, 2024050356. https://doi.org/10.20944/preprints202405.0356.v1 Halvatsiotis, P.; Tsokaki, T.; Tsitsis, V.; Palaiodimou, L.; Tsivgoulis, G.; Tsangaris, I.; Panagiotou, O.; Houhoula, D. IL-6 Polymorphism as a Predisposing Genetic Factor for Gestational Diabetes or Preeclampsia Development in Pregnancy with Obesity: VEGF and VEGFF Receptor Related Gene Expression Modalities. Preprints 2024, 2024050356. https://doi.org/10.20944/preprints202405.0356.v1

Abstract

The increased prevalence of obesity worldwide has been implicated for the alarming rise of the incidence of gestational diabetes and preeclampsia as well, both considered as threatening conditions for both mother and fetus. We studied gene polymorphisms of the proinflammatory cytokine Interleukin 6 (IL-6) and the gene expression levels of VEGF and VEGF-receptor all known to be involved in pregnancy complications aiming to identify possible predisposing risk factors in pregnancies with obesity. G allele of IL-6 was found to correspond with an increased risk for gestational diabetes and preeclampsia occurrence. Furthermore, in obese pregnant mothers with either gestational diabetes or pre-existing type 2 diabetes and to those developed preeclampsia it was confirmed that gene expression levels of VEGF were reduced while they were increased for VEGF receptor. We conclude that the genetic profile of the obese pregnant woman shares a common background with that of a pre-existing type 2 diabetes mellitus and therefore predisposes to complications in pregnancy.

Keywords

pregnancy; obesity; gestational diabetes; preeclampsia; interleukin 6; VEGF; VEGF receptor; type 2 diabetes mellitus 

Subject

Biology and Life Sciences, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.