Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of Oregano (Origanum vulgare) and Salvia triloba Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria

Maria Antoniadou; Georgios Rozos; Natalia Vaou; Konstantinos Zaralis; Caglar Ersanli; Athanasios Alexopoulos; Aikaterini Dadamogia; Theodoros Varzakas; Athina Tzora; Chrysoula (Chrysa) Voidarou

doi:10.20944/preprints202405.0246.v1

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preprints.org > medicine and pharmacology > dentistry and oral surgery > doi: 10.20944/preprints202405.0246.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of Oregano (Origanum vulgare) and Salvia triloba Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria

^* ,

Athanasios Alexopoulos

Aikaterini Dadamogia

Theodoros Varzakas

Athina Tzora

^* ,

Chrysoula (Chrysa) Voidarou

Version 1 : Received: 4 May 2024 / Approved: 6 May 2024 / Online: 6 May 2024 (08:55:46 CEST)

How to cite: Antoniadou, M.; Rozos, G.; Vaou, N.; Zaralis, K.; Ersanli, C.; Alexopoulos, A.; Dadamogia, A.; Varzakas, T.; Tzora, A.; Voidarou, C. (. Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of Oregano (Origanum vulgare) and Salvia triloba Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria. Preprints 2024, 2024050246. https://doi.org/10.20944/preprints202405.0246.v1 Antoniadou, M.; Rozos, G.; Vaou, N.; Zaralis, K.; Ersanli, C.; Alexopoulos, A.; Dadamogia, A.; Varzakas, T.; Tzora, A.; Voidarou, C. (. Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of Oregano (Origanum vulgare) and Salvia triloba Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria. Preprints 2024, 2024050246. https://doi.org/10.20944/preprints202405.0246.v1

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MDPI and ACS Style

Antoniadou, M.; Rozos, G.; Vaou, N.; Zaralis, K.; Ersanli, C.; Alexopoulos, A.; Dadamogia, A.; Varzakas, T.; Tzora, A.; Voidarou, C. (. Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of Oregano (Origanum vulgare) and Salvia triloba Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria. Preprints 2024, 2024050246. https://doi.org/10.20944/preprints202405.0246.v1

APA Style

Antoniadou, M., Rozos, G., Vaou, N., Zaralis, K., Ersanli, C., Alexopoulos, A., Dadamogia, A., Varzakas, T., Tzora, A., & Voidarou, C. (. (2024). Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of Oregano (Origanum vulgare) and Salvia triloba Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria. Preprints. https://doi.org/10.20944/preprints202405.0246.v1

Chicago/Turabian Style

Antoniadou, M., Athina Tzora and Chrysoula (Chrysa) Voidarou. 2024 "Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of Oregano (Origanum vulgare) and Salvia triloba Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria" Preprints. https://doi.org/10.20944/preprints202405.0246.v1

Abstract

This study utilized phytochemical screening to conduct qualitative analysis of plant extracts, aiming to identify various classes of secondary metabolites. Moreover, the antibacterial activity of different types of O. vulgare and S. triloba extracts was determined. To achieve the aim of the study, aqueous, ethanolic, and enzymatic extracts were prepared and screened for phytochemical capacity and antioxidant activities. Determination of the antibacterial activity included phenotypic screening of antibiotic susceptibility pattern of oral and food pathogenic bacterial strains, determination of Minimum inhibitory concentration and minimum bactericidal concentration - Microdilution broth test and in vitro valuation of antibacterial efficacies - anti-biofilm properties of the studied herbal extractions. Results: Our study evaluated the phytochemical composition and the antioxidant, antibacterial, and anti-biofilm properties of O. vulgare and S. triloba extracts. The analyzed samples contained bioactive compounds, such as phenolics and flavonoids, contributing to the observed strong antioxidant effect. Furthermore, they exhibited notable activity against oral biofilm formation and demonstrated significant antibacterial efficacy against dental caries microorganisms as well as food pathogens. Despite methodological variations, all extracts showed significant antioxidant capacity and promising antibacterial activity against various pathogens, including resistant strains, while also inhibiting biofilm formation. Although limited to two plant species and facing methodological constraints, the study lays a groundwork for future research, indicating the therapeutic potential of O. vulgare and S. triloba extracts. Further exploration is needed to report on underlying mechanisms and validate efficacy through clinical trials.

Keywords

Origanum vulgare; Salvia triloba extracts; phytochemistry and biological capacity; oral cariogenic and food-origin pathogenic bacteria

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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