Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Human Papillomavirus Vaccination Status among Fertility Patients

Version 1 : Received: 22 April 2024 / Approved: 23 April 2024 / Online: 23 April 2024 (17:14:19 CEST)

How to cite: Tarrash, M.; Brenner, E.; Brownridge, S.R.; Kapedani, A.; Goldman, R.H.; Goldberg, G.L.; Mullin, C. Human Papillomavirus Vaccination Status among Fertility Patients. Preprints 2024, 2024041541. https://doi.org/10.20944/preprints202404.1541.v1 Tarrash, M.; Brenner, E.; Brownridge, S.R.; Kapedani, A.; Goldman, R.H.; Goldberg, G.L.; Mullin, C. Human Papillomavirus Vaccination Status among Fertility Patients. Preprints 2024, 2024041541. https://doi.org/10.20944/preprints202404.1541.v1

Abstract

Human papillomavirus (HPV) can potentially compromise both unassisted conception and success rates with assisted reproductive technology (ART). We aimed to evaluate the rates of HPV vaccination among women presenting for fertility care. This was a prospective study analyzing a self-reported intake form completed by all new patients presenting to a fertility clinic. The primary outcome was HPV vaccination status. Among the 523 new patients included in this study 172 (32.9%) were fully vaccinated, 237 (45.3%) were unvaccinated, and 95 (18.2%) patients didn’t respond. There was a significant age difference between fully vaccinated patients (33.1 years) compared to unvaccinated patients (37.4 years) p<0.001 and a significant difference in gravidity between fully vaccinated patients (average 0.65) and unvaccinated patients (average 1.11) p=0.0005. No significant association was found between HPV vaccination status and history of abnormal Pap smears or relationship status (single vs. married). Less than half of patients presenting to our fertility center were vaccinated against HPV, despite being eligible to receive the vaccine. Younger patients with lower gravidity were more likely to be vaccinated against HPV than older patients with higher gravidity. Reproductive Endocrinologists have the opportunity to recommend HPV vaccination for eligible patients presenting for fertility care.

Keywords

Human papillomavirus (HPV); vaccination; infertility

Subject

Public Health and Healthcare, Primary Health Care

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