Version 1
: Received: 22 April 2024 / Approved: 22 April 2024 / Online: 23 April 2024 (10:08:32 CEST)
How to cite:
Kim, N.; Byun, S.; Um, S. Additional Sex Combs-Like Family Associated with Epigenetic Regulation. Preprints2024, 2024041480. https://doi.org/10.20944/preprints202404.1480.v1
Kim, N.; Byun, S.; Um, S. Additional Sex Combs-Like Family Associated with Epigenetic Regulation. Preprints 2024, 2024041480. https://doi.org/10.20944/preprints202404.1480.v1
Kim, N.; Byun, S.; Um, S. Additional Sex Combs-Like Family Associated with Epigenetic Regulation. Preprints2024, 2024041480. https://doi.org/10.20944/preprints202404.1480.v1
APA Style
Kim, N., Byun, S., & Um, S. (2024). Additional Sex Combs-Like Family Associated with Epigenetic Regulation. Preprints. https://doi.org/10.20944/preprints202404.1480.v1
Chicago/Turabian Style
Kim, N., Sukyoung Byun and Soo-Jong Um. 2024 "Additional Sex Combs-Like Family Associated with Epigenetic Regulation" Preprints. https://doi.org/10.20944/preprints202404.1480.v1
Abstract
The additional sex combs-like (ASXL) family, a mammalian homolog of the additional sex combs (Asx) of Drosophila, has been implicated in transcriptional regulation via chromatin modifications. Abnormal expression of ASXL family genes leads to myelodysplastic syndromes and various types of leukemia. De novo mutation of these genes also causes developmental disorders. Genes in this family and neighbor genes are evolutionary conserved in humans and mice. This review provides a comprehensive summary of epigenetic regulations associated with ASXL family genes. Their expression is commonly regulated by DNA methylation at CpG islands preceding transcription starting sites. Their proteins primarily engage in histone tail modifications through interactions with chromatin regulators (PRC2, trithorax complex, PR-DUB, SRC1, HP1α, and BET proteins), and with transcription factors, including nuclear hormone receptors (RAR, PPAR, ER, and LXR). Recently, non-coding RNAs have been identified following mutations in the ASXL1 or ASXL3 gene, along with circular ASXLs and microRNAs that regulate ASXL1 expression. The diverse epigenetic regulations linked to ASXL family genes collectively contribute to tumor suppression and developmental processes. Our understanding of ASXL-regulated epigenetics may provide insights into the development of therapeutic epigenetic drugs.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
