Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Innovative Approaches and Emerging Paradigms: A Literature Review on Novel Therapeutic Strategies in Organ Transplantation

Version 1 : Received: 18 April 2024 / Approved: 19 April 2024 / Online: 23 April 2024 (10:48:36 CEST)

How to cite: Rangraze, I.; Khan, S.; Jhancy, M.; Dube, R.; Goud, B.K.M.; Kar, S.; Wali, A.F. Innovative Approaches and Emerging Paradigms: A Literature Review on Novel Therapeutic Strategies in Organ Transplantation. Preprints 2024, 2024041335. https://doi.org/10.20944/preprints202404.1335.v1 Rangraze, I.; Khan, S.; Jhancy, M.; Dube, R.; Goud, B.K.M.; Kar, S.; Wali, A.F. Innovative Approaches and Emerging Paradigms: A Literature Review on Novel Therapeutic Strategies in Organ Transplantation. Preprints 2024, 2024041335. https://doi.org/10.20944/preprints202404.1335.v1

Abstract

The literature study delves into novel therapeutic strategies in transplantation medicine, highlighting unique approaches that could revolutionize current practices. It emphasizes novel patterns that have the potential to transform the current landscape. Commencing with a thorough examination of the historical environment, it traces crucial advances and changes in transplantation. The focus is on traditional techniques, emphasizing their limitations and challenges. An extensive examination of contemporary transplantation therapies offers valuable insights into the most recent progress in organ, cellular, and tissue transplantation. This analysis examines the immunological obstacles and outlines the current advancements and constraints. The exploration further navigates into novel models and concepts such as immunomodulation, developments in organ preservation techniques, gene editing, biomaterials, scaffold-based solutions, and the integration of precision medicine, artificial intelligence, and machine learning applications. Each section analyzes the potential for change and current progress in various areas, backed by relevant scientific sources up to 2023. The subsequent sections delve into innovative cellular therapies, biotechnological progress, current clinical trials, and case studies demonstrating effective applications. This examination delves into the ethical and regulatory considerations of innovative therapeutic procedures, emphasizing ethical implications, regulatory frameworks, and the importance of balancing innovation with patient welfare. The literature review concludes by offering a forward-looking perspective, emphasizing potential progress, anticipated challenges, and advocating for collaboration and interdisciplinary approaches to overcome limitations in the field of transplantation medicine.

Keywords

transplantation; donor; recipient; patient survival; graft; Precision medicine; Gene editing

Subject

Medicine and Pharmacology, Transplantation

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