The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma

Ilaria Baglivo; Vitaliano Nicola Quaranta; Silvano Dragonieri; Stefania Colantuono; Francesco Menzella; David Selvaggio; Giovanna Elisiana Carpagnano; Cristiano Caruso

doi:10.20944/preprints202404.1324.v1

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preprints.org > medicine and pharmacology > immunology and allergy > doi: 10.20944/preprints202404.1324.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma

Ilaria Baglivo

^* ,

Vitaliano Nicola Quaranta

Giovanna Elisiana Carpagnano

Cristiano Caruso

Version 1 : Received: 19 April 2024 / Approved: 19 April 2024 / Online: 19 April 2024 (10:38:26 CEST)

How to cite: Baglivo, I.; Quaranta, V.N.; Dragonieri, S.; Colantuono, S.; Menzella, F.; Selvaggio, D.; Carpagnano, G.E.; Caruso, C. The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma. Preprints 2024, 2024041324. https://doi.org/10.20944/preprints202404.1324.v1 Baglivo, I.; Quaranta, V.N.; Dragonieri, S.; Colantuono, S.; Menzella, F.; Selvaggio, D.; Carpagnano, G.E.; Caruso, C. The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma. Preprints 2024, 2024041324. https://doi.org/10.20944/preprints202404.1324.v1

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MDPI and ACS Style

Baglivo, I.; Quaranta, V.N.; Dragonieri, S.; Colantuono, S.; Menzella, F.; Selvaggio, D.; Carpagnano, G.E.; Caruso, C. The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma. Preprints 2024, 2024041324. https://doi.org/10.20944/preprints202404.1324.v1

APA Style

Baglivo, I., Quaranta, V.N., Dragonieri, S., Colantuono, S., Menzella, F., Selvaggio, D., Carpagnano, G.E., & Caruso, C. (2024). The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma. Preprints. https://doi.org/10.20944/preprints202404.1324.v1

Chicago/Turabian Style

Baglivo, I., Giovanna Elisiana Carpagnano and Cristiano Caruso. 2024 "The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma" Preprints. https://doi.org/10.20944/preprints202404.1324.v1

Abstract

Epithelial barrier damage plays a central role in the development and maintenance of allergic inflammation. The rise in airways epithelial barrier permeability alters the tissue homeostasis and allows the allergen and other external agents penetration. Different factors contribute to barrier impairment, such as eosinophilic infiltrate and allergens proteases action: the eosinophilic cationic proteins and the allergens' proteolytic activity have a central role in contributing to epithelial damage. In the airways, the allergens proteases degrade the epithelial junctional proteins allowing the allergen penetration and the uptake by dendritic cells. The increase in allergen-immune system interactions induce the release of the alarmins and the activation of type 2 inflammatory pathways causing, or worsening, the main symptoms at skin, bowel and respiratory levels. We aim to highlight the molecular mechanisms underlying allergenic proteases-induced epithelial barrier damage and the role of immune response in allergic asthma onset, maintenance and progression. We further will explore clinical and radiological potential biomarkers of airways remodeling in allergic asthma patients.

Keywords

allergic asthma; epithelial barrier damage; protease allergen; type 2 inflammation; airway remodeling

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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