Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Brazilian Borreliosis: An In-depth Review of Incidence, Diagnostic Challenges, and Awareness Efforts in Brazil

Version 1 : Received: 15 April 2024 / Approved: 16 April 2024 / Online: 16 April 2024 (10:48:16 CEST)

How to cite: Alcon-Chino, M.E.; De-Simone, S.G. Brazilian Borreliosis: An In-depth Review of Incidence, Diagnostic Challenges, and Awareness Efforts in Brazil. Preprints 2024, 2024041046. https://doi.org/10.20944/preprints202404.1046.v1 Alcon-Chino, M.E.; De-Simone, S.G. Brazilian Borreliosis: An In-depth Review of Incidence, Diagnostic Challenges, and Awareness Efforts in Brazil. Preprints 2024, 2024041046. https://doi.org/10.20944/preprints202404.1046.v1

Abstract

In Brazil, Brazilian borreliosis (BB), characterized molecularly, exhibits symptoms akin to Lyme disease (LD) but presents unique epidemiological, clinical, and morphological features. This study explores the incidence, diagnostic challenges, and awareness initiatives regarding this disease in Brazil. Employing a narrative review methodology, data were sourced from Pubmed, Ebsco, Google Scholar, and Web of Science without temporal constraints. Results reveal diagnostic complexities in Brazil due to the low sensitivity of conventional tests and the use of North American B. burgdorferi antigens. Despite challenges, epidemiological studies indicate an upswing in cases in humans and animals. Therefore, there is an urgent need to define new biomarkers, molecular strategies, or new antigenic targets to advance the development of vaccines and diagnostics. Early and accurate pathogen identification is crucial for active surveillance to comprehend and manage this zoonosis.

Keywords

Lyme disease; neuroborreliosis; diagnose; immunological diagnosis

Subject

Biology and Life Sciences, Parasitology

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