Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Perceptions of COVID-19 Vaccination among Organ Transplant Recipients

Version 1 : Received: 15 April 2024 / Approved: 16 April 2024 / Online: 16 April 2024 (11:39:36 CEST)

How to cite: Lerner, R.; Arvanitis, P.; Guermazi, D.; Farmakiotis, D. Perceptions of COVID-19 Vaccination among Organ Transplant Recipients. Preprints 2024, 2024041038. https://doi.org/10.20944/preprints202404.1038.v1 Lerner, R.; Arvanitis, P.; Guermazi, D.; Farmakiotis, D. Perceptions of COVID-19 Vaccination among Organ Transplant Recipients. Preprints 2024, 2024041038. https://doi.org/10.20944/preprints202404.1038.v1

Abstract

Understanding vaccine hesitancy in organ transplant recipients (OTR) is critical, given clear, alt-hough attenuated, benefits from vaccination. Adult OTR were surveyed regarding vaccine-related values and a novel outcome variable called Vaccine Acceptance Composite Score (VACS) was built as the average Likert score of 7 domains of vaccination confidence. Of 46 OTR included (93.5% kidney transplant recipients), 32.6% were female, 13.3% Black, 6.77% Hispan-ic/Latino/a/x; median age was 58 years. Patients were most concerned about COVID-19 vac-cine-associated risks (46.3%), its potential effect on allograft (47.6%) and motives of government officials involved with vaccine policy (55.6%). Politically conservative patients were likely to have a significantly lower VACS, while those who lived with someone ≥65 had a higher VACS. The VACS was not significantly associated with race, income, religious beliefs, comorbidities, COVID-19 history, or influenza vaccination status. Higher VACS was significantly associated with ≥3 and ≥4 COVID-19 immunizations. This study highlighted political beliefs and elderly household members as correlates of vaccine acceptance among OTR. The VACS may be a useful tool to help standardize multifaceted analyses in vaccination-focused behavioral research, as well as identify individuals and groups at risk for vaccine hesitancy, who may benefit from tai-lored outreach and educational interventions.

Keywords

COVID-19; vaccine; transplant; vaccine hesitancy; vaccine attitudes; public health

Subject

Medicine and Pharmacology, Transplantation

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