Rosdi, Q.F.; Bahri, A.A.S. Inhibitory Effects of Nicotinic Acid against Streptococcus pneumoniae Biofilm. Preprints2024, 2024041020. https://doi.org/10.20944/preprints202404.1020.v1
APA Style
Rosdi, Q.F., & Bahri, A.A.S. (2024). Inhibitory Effects of Nicotinic Acid against <em>Streptococcus pneumoniae </em>Biofilm. Preprints. https://doi.org/10.20944/preprints202404.1020.v1
Chicago/Turabian Style
Rosdi, Q.F. and Ahmad Asyraf Saiful Bahri. 2024 "Inhibitory Effects of Nicotinic Acid against <em>Streptococcus pneumoniae </em>Biofilm" Preprints. https://doi.org/10.20944/preprints202404.1020.v1
Abstract
This study was performed to evaluate the efficacy of nicotinic acid against Streptococcus pneumoniae biofilm. The experimental results indicate that S. pneumoniae forms biofilms, particularly at the liquid-air interface, as evidenced by the pellicle assay. Nicotinic acid demonstrated significant inhibition of S. pneumoniae biofilm formation at 6 h and 18 h, with higher concentrations leading to lower biofilm biomass, suggesting a concentration-dependent response. However, minimal biofilm inhibition was observed at 12 h. Treatment with nicotinic acid induced FTIR spectral changes in protein biomolecules of S. pneumoniae biofilm at 6 h and 18 h, evidenced by alterations in spectral peaks at 750 cm-1, 906 cm-1, 1540 cm-1, 1548 cm-1, and 1644 cm-1. Notably, no FTIR spectral changes were detected in 12 h S. pneumoniae biofilm following exposure to nicotinic acid. These findings suggest that nicotinic acid inhibits biofilm formation in a time and concentration-dependent manner, possibly by altering the structure of protein biomolecules within the biofilm.
Keywords
Streptococcus pneumoniae; biofilm; nicotinic acid
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
