CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

David Sanchis-Pascual; María Isabel Del Olmo-García; Stefan Prado-Wohlwend; Carlos Zac; Ángel Segura Huerta; Javier Hernández-Gil; Luis Martí-Bonmatí; Juan F. Merino-Torres

doi:10.20944/preprints202404.0951.v1

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preprints.org > medicine and pharmacology > endocrinology and metabolism > doi: 10.20944/preprints202404.0951.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

David Sanchis-Pascual

^* ,

María Isabel Del Olmo-García

Stefan Prado-Wohlwend

Juan F. Merino-Torres

Version 1 : Received: 13 April 2024 / Approved: 15 April 2024 / Online: 15 April 2024 (10:16:17 CEST)

How to cite: Sanchis-Pascual, D.; Del Olmo-García, M.I.; Prado-Wohlwend, S.; Zac, C.; Segura Huerta, Á.; Hernández-Gil, J.; Martí-Bonmatí, L.; Merino-Torres, J.F. CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms. Preprints 2024, 2024040951. https://doi.org/10.20944/preprints202404.0951.v1 Sanchis-Pascual, D.; Del Olmo-García, M.I.; Prado-Wohlwend, S.; Zac, C.; Segura Huerta, Á.; Hernández-Gil, J.; Martí-Bonmatí, L.; Merino-Torres, J.F. CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms. Preprints 2024, 2024040951. https://doi.org/10.20944/preprints202404.0951.v1

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MDPI and ACS Style

Sanchis-Pascual, D.; Del Olmo-García, M.I.; Prado-Wohlwend, S.; Zac, C.; Segura Huerta, Á.; Hernández-Gil, J.; Martí-Bonmatí, L.; Merino-Torres, J.F. CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms. Preprints 2024, 2024040951. https://doi.org/10.20944/preprints202404.0951.v1

APA Style

Sanchis-Pascual, D., Del Olmo-García, M.I., Prado-Wohlwend, S., Zac, C., Segura Huerta, Á., Hernández-Gil, J., Martí-Bonmatí, L., & Merino-Torres, J.F. (2024). CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms. Preprints. https://doi.org/10.20944/preprints202404.0951.v1

Chicago/Turabian Style

Sanchis-Pascual, D., Luis Martí-Bonmatí and Juan F. Merino-Torres. 2024 "CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms" Preprints. https://doi.org/10.20944/preprints202404.0951.v1

Abstract

There are several well-described molecular mechanisms that influence cell growth and are relat-ed to the development of cancer. Chemokines constitute a fundamental element which are not only involved in local growth but also affect angiogenesis, tumor spread and metastatic disease. Among them, the C-X-C motif chemokine ligand 12 (CXCL12) and its specific receptor the chemo-kine C-X-C motif receptor 4 (CXCR4) have been widely studied. The overexpression in cell mem-branes of CXCR4 has been shown to be associated with the development of different kinds of his-tological malignancies, such as adenocarcinomas, epidermoid carcinomas, mesenchymal tumors or neuroendocrine neoplasms (NENs). The molecular synapsis between CXCL12 and CXCR4 leads to the interaction of G proteins and activation of different intracellular signaling pathways in both gastroenteropancreatic (GEP) and bronchopulmonary (BP) NENs conferring greater ca-pacity for locoregional aggressiveness, epithelial-mesenchymal transition (EMT) and the ap-pearance of metastases. Therefore, it has been hypothesized how to design tools that target this receptor. The aim of this review is to focus on current knowledge of the relationship between CXCR4 and NENs, with a special emphasis on diagnostic and therapeutic molecular targets.

Keywords

CXCR4; CXCL12; cancer; neuroendocrine neoplasm; radiotracer

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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