PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Synergistic Effect of Terbinafine and Blue Light on Reactive Oxygen Species Production in Human Keratinocytes: Potential Implications for Cutaneous Mycosis
Version 1
: Received: 9 April 2024 / Approved: 9 April 2024 / Online: 9 April 2024 (15:19:41 CEST)
How to cite:
Pérez-González, L.A.; Martínez-Pascual, M.A.; Toledano-Macías, E.; Jara-Laguna, R.C.; Fernández-Guarino, M.; Hernandez-Bule, M.L. Synergistic Effect of Terbinafine and Blue Light on Reactive Oxygen Species Production in Human Keratinocytes: Potential Implications for Cutaneous Mycosis. Preprints2024, 2024040684. https://doi.org/10.20944/preprints202404.0684.v1
Pérez-González, L.A.; Martínez-Pascual, M.A.; Toledano-Macías, E.; Jara-Laguna, R.C.; Fernández-Guarino, M.; Hernandez-Bule, M.L. Synergistic Effect of Terbinafine and Blue Light on Reactive Oxygen Species Production in Human Keratinocytes: Potential Implications for Cutaneous Mycosis. Preprints 2024, 2024040684. https://doi.org/10.20944/preprints202404.0684.v1
Pérez-González, L.A.; Martínez-Pascual, M.A.; Toledano-Macías, E.; Jara-Laguna, R.C.; Fernández-Guarino, M.; Hernandez-Bule, M.L. Synergistic Effect of Terbinafine and Blue Light on Reactive Oxygen Species Production in Human Keratinocytes: Potential Implications for Cutaneous Mycosis. Preprints2024, 2024040684. https://doi.org/10.20944/preprints202404.0684.v1
APA Style
Pérez-González, L.A., Martínez-Pascual, M.A., Toledano-Macías, E., Jara-Laguna, R.C., Fernández-Guarino, M., & Hernandez-Bule, M.L. (2024). Synergistic Effect of Terbinafine and Blue Light on Reactive Oxygen Species Production in Human Keratinocytes: Potential Implications for Cutaneous Mycosis. Preprints. https://doi.org/10.20944/preprints202404.0684.v1
Chicago/Turabian Style
Pérez-González, L.A., Montserrat Fernández-Guarino and Maria Luisa Hernandez-Bule. 2024 "Synergistic Effect of Terbinafine and Blue Light on Reactive Oxygen Species Production in Human Keratinocytes: Potential Implications for Cutaneous Mycosis" Preprints. https://doi.org/10.20944/preprints202404.0684.v1
Abstract
Cutaneous mycoses are common infections whose treatment has become more complex due to increasing antifungal resistance and the need for prolonged therapies, hindering patient adher-ence and increasing the incidence of adverse effects. Consequently, the use of physical therapies, especially photodynamic therapy (PDT), has increased for the treatment of onychomycosis due to its antimicrobial capacity mediated by the production of reactive oxygen species. This study investigates the in vitro effect of the combination of blue light (448 nm) and red light (645 nm) with terbinafine on the cell viability of human keratinocytes and the production of reactive ox-ygen species. The combination of terbinafine and blue light exhibits a synergistic effect on the production of reactive oxygen species and a significant increase in the expression of superoxide dismutase (SOD), an enzyme involved in the reduction of superoxide ions (O2-) and the genera-tion of hydrogen peroxide (H2O2). Such effect could be useful in clinical practice to improve the response of cutaneous mycoses to pharmacological treatment, reduce their toxicity, and shorten their duration.
Keywords
onychomycosis; physical therapies; keratinocytes; reactive oxygen species; blue light
Subject
Medicine and Pharmacology, Dermatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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