Version 1
: Received: 8 April 2024 / Approved: 8 April 2024 / Online: 8 April 2024 (15:44:26 CEST)
How to cite:
Gonçalves, A.C.; Rodrigues, S.; Rodrigues, R.; Silva, L.R. The Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports. Preprints2024, 2024040585. https://doi.org/10.20944/preprints202404.0585.v1
Gonçalves, A.C.; Rodrigues, S.; Rodrigues, R.; Silva, L.R. The Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports. Preprints 2024, 2024040585. https://doi.org/10.20944/preprints202404.0585.v1
Gonçalves, A.C.; Rodrigues, S.; Rodrigues, R.; Silva, L.R. The Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports. Preprints2024, 2024040585. https://doi.org/10.20944/preprints202404.0585.v1
APA Style
Gonçalves, A.C., Rodrigues, S., Rodrigues, R., & Silva, L.R. (2024). The Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports. Preprints. https://doi.org/10.20944/preprints202404.0585.v1
Chicago/Turabian Style
Gonçalves, A.C., Rafael Rodrigues and Luís R. Silva. 2024 "The Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports" Preprints. https://doi.org/10.20944/preprints202404.0585.v1
Abstract
Rheumatoid arthritis (RA) is a complex illness with both hereditary and environmental compo-nents. Globally, in 2019, 18 million people had RA. RA is characterised by persistent inflammation of the synovial membrane that lines the joints, cartilage loss, and bone erosion. Phenolic molecules are the most prevalent secondary metabolites in plants, with a diverse spectrum of biological ac-tions that benefit functional meals and nutraceuticals. These compounds have received a lot of at-tention recently because they have antioxidant, anti-inflammatory, immunomodulatory, and anti-rheumatoid activity by modulating tumour necrosis factor, mitogen-activated protein kinase, nu-clear factor kappa-light-chain-enhancer of activated B cells, and c-Jun N-terminal kinases, as well as other preventative properties. This article discusses dietary polyphenols, their pharmacological properties, and innovative delivery technologies for the treatment of RA, with a focus on their possible biological activities. Nonetheless, commercialization of polyphenols may be achievable only after confirming their safety profile and completing successful clinical trials.
Keywords
Anti-inflammatory activity; phenolic compounds; rheumatoid arthritis, diet, quality of life.
Subject
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
