Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Neurosurgical Intervention for Nerve and Muscle Biopsies

Version 1 : Received: 3 April 2024 / Approved: 4 April 2024 / Online: 4 April 2024 (10:11:25 CEST)

How to cite: Mohamed, A.A.; Caussat, T.; Mouhawasse, E.; Ali, R.; Johansen, P.M.; Lucke-Wold, B. Neurosurgical Intervention for Nerve and Muscle Biopsies. Preprints 2024, 2024040358. https://doi.org/10.20944/preprints202404.0358.v1 Mohamed, A.A.; Caussat, T.; Mouhawasse, E.; Ali, R.; Johansen, P.M.; Lucke-Wold, B. Neurosurgical Intervention for Nerve and Muscle Biopsies. Preprints 2024, 2024040358. https://doi.org/10.20944/preprints202404.0358.v1

Abstract

(1) Background: Neurologic and musculoskeletal diseases represent a considerable portion of the underlying etiologies responsible for the widely prevalent symptoms of pain, weakens, numbness, and paresthesia. Because of the subjective and often nonspecific nature of these symptoms, different diagnostic modalities have been explored and utilized.; (2) Methods: Literature review; (3) Results: Nerve and muscle biopsy remains the gold standard for diagnosing many of the responsible neurological and musculoskeletal conditions. However, the need for invasive tissue sampling is diminishing as more investigations explore alternative diagnostic modalities. Because of this, it is important to explore the current role of neurosurgical intervention for nerve and muscle biopsies and its current relevance in the diagnostic landscape of neurological and musculoskeletal disorders. With consideration of the role of nerve and muscle biopsy, it is also important to explore innovations and emerging techniques for conducting these procedures. This review explores the indications and emerging techniques for neurological intervention for nerve and muscle biopsies; (4) Conclusions: The role of neurosurgical intervention for nerve and muscle biopsy remains relevant in diagnosing many neurological and musculoskeletal disorders. Biopsy is especially relevant as a supportive point of evidence for diagnosis in atypical cases. Additionally, emerging techniques have been explored to guide diagnostics and biopsy, conduct less invasive biopsies, and reduce risks of worsening neurologic function and other symptoms secondary to biopsy.

Keywords

Nerve biopsy; neurosurgical biopsy; neuropathy; neuropathology; technique

Subject

Medicine and Pharmacology, Surgery

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