Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Impact of Early Surfactant Administration on Ductus Arteriosus Assessed at 24 Hours in Preterm Neonates Less than 32 Weeks of Gestational Age

Manuela Cucerea
ORCID logo ,
Mihaela Moscalu
* ,
Maria-Livia Ognean
ORCID logo ,
Amalia Fagarasan
,
Daniela Toma
,
Raluca Marian
,
Madalina Anciuc-Crauciuc
,
Andreea Racean
,
Zsuzsanna Gall
,
Marta Simon
Version 1 : Received: 3 April 2024 / Approved: 3 April 2024 / Online: 4 April 2024 (17:50:33 CEST)

How to cite: Cucerea, M.; Moscalu, M.; Ognean, M.; Fagarasan, A.; Toma, D.; Marian, R.; Anciuc-Crauciuc, M.; Racean, A.; Gall, Z.; Simon, M. Impact of Early Surfactant Administration on Ductus Arteriosus Assessed at 24 Hours in Preterm Neonates Less than 32 Weeks of Gestational Age. Preprints 2024, 2024040351. https://doi.org/10.20944/preprints202404.0351.v1 Cucerea, M.; Moscalu, M.; Ognean, M.; Fagarasan, A.; Toma, D.; Marian, R.; Anciuc-Crauciuc, M.; Racean, A.; Gall, Z.; Simon, M. Impact of Early Surfactant Administration on Ductus Arteriosus Assessed at 24 Hours in Preterm Neonates Less than 32 Weeks of Gestational Age. Preprints 2024, 2024040351. https://doi.org/10.20944/preprints202404.0351.v1

Abstract

Background and Objectives: The purpose of this study was to investigate whether early surfactant administration affects the status of ductus arteriosus (DA) in preterm infants ≤32 weeks of gestational age (GA) within 24 hours of birth. Materials and Methods: It is a prospective study conducted from March 15, 2022, to November 15, 2023, in a tertiary academic center. In-born infants ≤ 32 weeks of gestation (n = 88) were enrolled. The study group was further divided into surfactant (n=44) and non-surfactant (n=44) subgroups. Results: 76% of the preterm infants who received surfactant therapy (RRR = 0.839) recorded an increase in Kindler Score at 24 hours of life (1-RR = 1-0.24 = 76%). Surfactant administration was significantly associated with decreased pre-ductal diastolic pressure (29.9 mmHg vs. 34.8 mmHg, p=0.0231), post-ductal diastolic pressure (28.7 mmHg vs. 32.2 mmHg, p=0.0178) pre-ductal MAP (41.6 mmHg vs. 46.5 mmHg, p=0.0210) post-ductal MAP (41.0 mmHg vs. 45.3 mmHg, p=0.0336). There were no significant changes in ductus arteriosus parameters at 24 hours of life. Conclusions: Early surfactant administration does not affect the status of ductus arteriosus in preterm infants ≤32 weeks of gestational age at 24 hours of life.

Keywords

surfactant; ductus arteriosus; echographic parameters; preterm infants

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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