Version 1
: Received: 3 April 2024 / Approved: 3 April 2024 / Online: 3 April 2024 (16:07:30 CEST)
How to cite:
Biny, L.; Gerasimovich, E.; Karaulov, A.; Sukhanova, A.; Nabiev, I. Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment. Preprints2024, 2024040315. https://doi.org/10.20944/preprints202404.0315.v1
Biny, L.; Gerasimovich, E.; Karaulov, A.; Sukhanova, A.; Nabiev, I. Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment. Preprints 2024, 2024040315. https://doi.org/10.20944/preprints202404.0315.v1
Biny, L.; Gerasimovich, E.; Karaulov, A.; Sukhanova, A.; Nabiev, I. Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment. Preprints2024, 2024040315. https://doi.org/10.20944/preprints202404.0315.v1
APA Style
Biny, L., Gerasimovich, E., Karaulov, A., Sukhanova, A., & Nabiev, I. (2024). Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment. Preprints. https://doi.org/10.20944/preprints202404.0315.v1
Chicago/Turabian Style
Biny, L., Alyona Sukhanova and Igor Nabiev. 2024 "Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment" Preprints. https://doi.org/10.20944/preprints202404.0315.v1
Abstract
Nano- and microparticles are increasingly widely used in biomedical research and applications, particularly as specific labels and targeted delivery vehicles. Silica has long been considered the best material for such vehicles, but it has some disadvantages limiting its potential, such as the proneness of silica-based carriers to spontaneous drug release. Calcium carbonate (CaCO3) is an emerging alternative, being easily available, cost-effective, biocompatible material with high porosity and surface reactivity, which makes it an attractive choice for targeted drug delivery. CaCO3 particles are used in this field in the form of either bare CaCO3 microbeads or core/shell microparticles representing polymer-coated CaCO3 cores. In addition, they serve as removable templates for obtaining hollow polymer microcapsules. Each of these types of particles has its specific advantages in terms of biomedical applications. CaCO3 microbeads are primarily used due to their capacity for carrying pharmaceutics, whereas core/shell systems ensure better protection of the drug-loaded core from the environment. Hollow polymer capsules are particularly attractive because they can encapsulate large amounts of pharmaceutical agents and can be so designed as to release their contents in the target site in response to specific stimuli. This review focuses first on the chemistry of the CaCO3 cores, core/shell microbeads, and polymer microcapsules. Then, systems using these structures for the delivery of therapeutic agents, including drugs, proteins, and DNA, are outlined. The results of systematic analysis of available data are presented. They show that the encapsulation of various therapeutic agents in CaCO3-based microbeads or polymer microcapsules is a promising technique of drug delivery, especially in cancer therapy, enhancing drug bioavailability and specific targeting of cancer cells while reducing side effects. To date, research in CaCO3-based microparticles and polymer microcapsules assembled on CaCO3 templates has mainly dealt with their properties in vitro, whereas their in vivo behavior still remains poorly studied. However, an enormous potential of these highly biocompatible carriers for in vivo applications is undoubted. This last issue is addressed in depth in the Conclusion and Outlook sections of the review.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
