Version 1
: Received: 1 April 2024 / Approved: 2 April 2024 / Online: 2 April 2024 (10:09:33 CEST)
How to cite:
Seane, E.N.; Nair, S.; Vandevoorde, C.; Joubert, A. Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview. Preprints2024, 2024040176. https://doi.org/10.20944/preprints202404.0176.v1
Seane, E.N.; Nair, S.; Vandevoorde, C.; Joubert, A. Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview. Preprints 2024, 2024040176. https://doi.org/10.20944/preprints202404.0176.v1
Seane, E.N.; Nair, S.; Vandevoorde, C.; Joubert, A. Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview. Preprints2024, 2024040176. https://doi.org/10.20944/preprints202404.0176.v1
APA Style
Seane, E.N., Nair, S., Vandevoorde, C., & Joubert, A. (2024). Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview. Preprints. https://doi.org/10.20944/preprints202404.0176.v1
Chicago/Turabian Style
Seane, E.N., Charlot Vandevoorde and Anna Joubert. 2024 "Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview" Preprints. https://doi.org/10.20944/preprints202404.0176.v1
Abstract
Histone deacetylases inhibitors (HDACi) have shown promising therapeutic outcomes in haematological malignancies such as leu-kaemia, multiple myeloma and lymphoma, with dis-appointing results in solid tumours when used as monotherapy. As a result, combination therapies either with radiation or other deoxyribonucleic acid (DNA) damaging agents have been suggested as ideal strategy to improve their efficacy in solid tumours. Numerous in vitro and in vivo studies have demonstrated that HDACi can sensitise malignant cells to both electromagnetic and particle types of radiation by inhibiting DNA damage repair. Although the radiosensitising ability of HDACi has been reported as early as 1990s, the mechanisms of radiosensitisation are yet to be fully understood. This review brings forth the various protocols used to sequence the administration of radiation and HDACi treatments in the different studies. The possible contribution of these various protocols on the ambiguity that surrounds the mechanisms of radiosensitisation is also highlighted.
Keywords
histone deacetylase inhibitors; radiosensitisation; heterochromatin; double strand break; DNA repair
Subject
Biology and Life Sciences, Biophysics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
