Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Growth and Neurodevelopmental Outcomes of Preterm Infants Born <26 weeks Gestation Before and After Implementation of a Nutrition Care Bundle

Giulia Res
,
Rosine F Bishara
ORCID logo ,
Paige Terrien Church
,
Rena Rosenthal
,
Rita Maria Bishara
,
Annie Dupuis
ORCID logo ,
Elizabeth Azstalos
,
Rudaina Banihani
* ORCID logo
Version 1 : Received: 31 March 2024 / Approved: 1 April 2024 / Online: 1 April 2024 (12:24:33 CEST)

A peer-reviewed article of this Preprint also exists.

Res, G.; Bishara, R.F.; Church, P.T.; Rosenthal, R.; Bishara, R.M.; Dupuis, A.; Asztalos, E.; Banihani, R. Growth and Neurodevelopmental Outcomes of Preterm Infants Born < 26 Weeks Gestation before and after Implementation of a Nutrition-Care Bundle. Children 2024, 11, 475. Res, G.; Bishara, R.F.; Church, P.T.; Rosenthal, R.; Bishara, R.M.; Dupuis, A.; Asztalos, E.; Banihani, R. Growth and Neurodevelopmental Outcomes of Preterm Infants Born &lt; 26 Weeks Gestation before and after Implementation of a Nutrition-Care Bundle. Children 2024, 11, 475.

Abstract

Background: This study aimed to assess the impact of a nutrition-care bundle on growth and neurodevelopmental outcomes of micro-preterm infants born in a level III neonatal intensive care unit (NICU) by two years corrected age. Methods: A nutrition-care bundle emphasizing the prompt initiation of parenteral nutrition at birth, initiation of enteral feeds within 6 hours after birth, and early addition of human milk fortifiers was implemented in 2015 for infants born &lt;26 weeks gestation. This before-and-after study evaluated growth and neurodevelopmental outcomes in infants born between 2012-2013 (before-nutrition-bundle BNB) and 2016-2017 (after-nutrition-bundle ANB). Results: A total of 145 infants were included in the study. Infants in the ANB group (n=73) were smaller (birthweight and gestational age), and there were more male infants and multiples included compared to the BNB group (n=72). Enteral feeds and fortifiers started earlier in the ANB group. Growth velocity and weight-z-score changes were similar in both groups during NICU stay and post-discharge. Systemic steroid use, but not cohort, was linked to lower Bayley scores across all domains. Conclusions: Implementing a nutrition-care bundle was not consistently associated with improved weight-gain and neurodevelopmental outcomes in the micro-preterm infant population, likely due to ongoing high-quality nutritional care by the clinical team.

Keywords

Growth; neurodevelopmental outcomes; micro-preterm; nutrition bundle

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.