Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers and Therapeutic Targets for the Metabolic Bone Disease

Version 1 : Received: 29 March 2024 / Approved: 1 April 2024 / Online: 1 April 2024 (17:09:17 CEST)

How to cite: Wang, J.; Xue, M.; Hu, Y.; Li, J.; Li, Z.; Wang, Y. Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers and Therapeutic Targets for the Metabolic Bone Disease. Preprints 2024, 2024040054. https://doi.org/10.20944/preprints202404.0054.v1 Wang, J.; Xue, M.; Hu, Y.; Li, J.; Li, Z.; Wang, Y. Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers and Therapeutic Targets for the Metabolic Bone Disease. Preprints 2024, 2024040054. https://doi.org/10.20944/preprints202404.0054.v1

Abstract

Osteoporosis (OP), a prevalent skeletal disorder characterized by compromised bone strength and increased susceptibility to fractures, poses a significant public health concern. This review aims to provide a comprehensive analysis of the current state of research in the field, focusing on the application of proteomic techniques to elucidate diagnostic markers and therapeutic targets for OP. The integration of cutting-edge proteomic technologies has enabled the identification and quantification of proteins associated with bone metabolism, leading to a deeper understanding of the molecular mechanisms underlying OP. In this review, we systematically examine recent advancements in proteomic studies related to OP, emphasizing the identification of potential biomarkers for OP diagnosis and the discovery of novel therapeutic targets. Additionally, we discuss the challenges and future directions in the field, highlighting the potential impact of proteomic research in transforming the landscape of OP diagnosis and treatment.

Keywords

osteoporosis; bone metabolism; proteomics; diagnostic biomarkers; therapeutic targets

Subject

Biology and Life Sciences, Life Sciences

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