Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Efficacy of Polyhexamethylene Biguanide (Polyhexanide or PHMB) in Pediatric Superficial Partial-Thickness Burns: Outcomes and Influencing Factors

Aba Lőrincz
ORCID logo ,
Hermann Nudelman
,
Anna Gabriella Lamberti
,
András Garami
ORCID logo ,
Krisztina Adrienne Tiborcz
,
Tamás Zoltán Kovács
,
Gergő Józsa
* ORCID logo
Version 1 : Received: 25 March 2024 / Approved: 25 March 2024 / Online: 26 March 2024 (11:56:58 CET)

How to cite: Lőrincz, A.; Nudelman, H.; Lamberti, A.G.; Garami, A.; Tiborcz, K.A.; Kovács, T.Z.; Józsa, G. Efficacy of Polyhexamethylene Biguanide (Polyhexanide or PHMB) in Pediatric Superficial Partial-Thickness Burns: Outcomes and Influencing Factors. Preprints 2024, 2024031513. https://doi.org/10.20944/preprints202403.1513.v1 Lőrincz, A.; Nudelman, H.; Lamberti, A.G.; Garami, A.; Tiborcz, K.A.; Kovács, T.Z.; Józsa, G. Efficacy of Polyhexamethylene Biguanide (Polyhexanide or PHMB) in Pediatric Superficial Partial-Thickness Burns: Outcomes and Influencing Factors. Preprints 2024, 2024031513. https://doi.org/10.20944/preprints202403.1513.v1

Abstract

In pediatric burn care, achieving swift healing with minimal complications remains paramount. This investigation assesses polyhexamethylene biguanide (PHMB)'s role in managing superficial partial-thickness burns in children, focusing on the effects of various patient-specific factors on recovery. Through a retrospective analysis of 27 pediatric cases treated with PHMB, we explored the impact of age, burn size, dressing frequency, treatment delay, cold therapy application, and analgesic usage on the duration until reepithelialization. Notably, the majority of patients benefited from early cold therapy, yet only 1 in 3 patients received analgesics. The study reveals a mean healing time of 8.78 days, with the extent of the burn showing a strong correlation to recovery speed. Most treatments were managed outpatient, evidenced by a negligible average hospital stay. Impressively, the intervention recorded no complications. Our findings endorse PHMB as a promising treatment for second-degree burns in young patients, offering healing efficiency on par with or surpassing traditional methods, without increasing complication risks. This investigation underscores the necessity for continued exploration into the optimal application of prehospital interventions and the comprehensive benefits of PHMB in pediatric burn management, advocating for future research aimed at assessing long-term outcomes, including scar quality and patient satisfaction.

Keywords

Pediatric; Child; Partial-thickness; Second-degree; Burn; PHMB; Polyhexanide; Polyhexamethylen Biguanide

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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