Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Trajectories of State-Level Sepsis-Related Mortality by Race and Ethnicity Group in the United States

Version 1 : Received: 22 March 2024 / Approved: 25 March 2024 / Online: 25 March 2024 (11:11:17 CET)

How to cite: Oud, L.; Garza, J. Trajectories of State-Level Sepsis-Related Mortality by Race and Ethnicity Group in the United States. Preprints 2024, 2024031462. https://doi.org/10.20944/preprints202403.1462.v1 Oud, L.; Garza, J. Trajectories of State-Level Sepsis-Related Mortality by Race and Ethnicity Group in the United States. Preprints 2024, 2024031462. https://doi.org/10.20944/preprints202403.1462.v1

Abstract

Background: Recent reports on the national temporal trends of sepsis-related mortality in the United States (US) suggested outcome improvement in several race and ethnicity groups. However, it is unknown whether national data reflect state-level trajectories. Methods: We used the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research Multiple Cause of Death dataset to identify all decedents with sepsis in the US during 2010-2019. Negative binomial regression models were fit to estimate national and state-level trends of age-adjusted sepsis-related mortality rates within race and ethnicity groups. Results: There were 1,852,610 sepsis-related deaths in the US during 2010-2019. Nationally, sepsis-related mortality rates decreased among Blacks and Asians, were unchanged among Hispanics and Native Americans, and rose among Whites. The percent of states with similar trends were 30.0% among Blacks, 32.1% among Asians, 74.3% among Hispanics, 75.0% among Native Americans, and 66.7%% among Whites, while trending in opposite direction from 3.6% among Asians to 15.0% among Blacks. Conclusions: National trends in sepsis-related mortality in the US did not represent state-level trajectories in race and ethnicity groups. Gains in sepsis outcomes among race and ethnicity groups at the national level were not shared equitably at the state level.

Keywords

Disparity; ethnicity; mortality; race; sepsis; states

Subject

Public Health and Healthcare, Public Health and Health Services

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