The Dysregulation of the Monocyte-Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia

Domenico Galati; Domenico Mallardo; Carmine Nicastro; Serena Zanotta; Ludovica Capitelli; Carmen Lombardi; Bianca Baino; Ernesta Cavalcanti; Silvia Sale; Francesco Labonia; Rita Boenzi; Luigi Atripaldi; Paolo Antonio Ascierto; Marialuisa Bocchino

doi:10.20944/preprints202403.1213.v1

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preprints.org > medicine and pharmacology > immunology and allergy > doi: 10.20944/preprints202403.1213.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Dysregulation of the Monocyte-Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia

Paolo Antonio Ascierto

Marialuisa Bocchino

Version 1 : Received: 19 March 2024 / Approved: 20 March 2024 / Online: 21 March 2024 (02:17:02 CET)

A peer-reviewed article of this Preprint also exists.

Galati, D.; Mallardo, D.; Nicastro, C.; Zanotta, S.; Capitelli, L.; Lombardi, C.; Baino, B.; Cavalcanti, E.; Sale, S.; Labonia, F.; Boenzi, R.; Atripaldi, L.; Ascierto, P.A.; Bocchino, M. The Dysregulation of the Monocyte–Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia. J. Clin. Med. 2024, 13, 2481. Galati, D.; Mallardo, D.; Nicastro, C.; Zanotta, S.; Capitelli, L.; Lombardi, C.; Baino, B.; Cavalcanti, E.; Sale, S.; Labonia, F.; Boenzi, R.; Atripaldi, L.; Ascierto, P.A.; Bocchino, M. The Dysregulation of the Monocyte–Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia. J. Clin. Med. 2024, 13, 2481.

Abstract

Background: The monocyte-phagocyte system (MPS), including monocytes/macrophages and dendritic cells (DCs), plays a key role in anti-viral immunity. We aimed to analyze the prognostic value of the MPS components on in-hospital mortality in a cohort of 58 patients (M/F ; mean ageSD years) with COVID-19 pneumonia and 22 age- and sex-matched healthy controls. Methods: We measured frequencies and absolute numbers of peripheral blood CD169+ monocytes, conventional CD1c+ and CD141+ (namely cDC2 and cDC1), and plasmacytoid CD303+ DCs by means of multi-parametric flow cytometry. A gene profile analysis of 770 immune-inflammatory related human genes and 20 SARS-CoV-2 genes was also performed. Results: Median frequencies and absolute counts of CD169-expressing monocytes were significantly higher in COVID-19 patients than in controls (p 0.04 and p 0.01, respectively). Conversely, percentages and absolute numbers of all DC subsets were markedly depleted in patients (p

Keywords

COVID-19; Sars-CoV-2; Dendritic cells; Monocytes CD169; Gene profile analysis

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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