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Using Physics-Informed Neural Networks (PINNs) for Tumor Cells Growth Modeling
Version 1
: Received: 15 March 2024 / Approved: 18 March 2024 / Online: 18 March 2024 (10:29:13 CET)
A peer-reviewed article of this Preprint also exists.
Rodrigues, J.A. Using Physics-Informed Neural Networks (PINNs) for Tumor Cell Growth Modeling. Mathematics 2024, 12, 1195. Rodrigues, J.A. Using Physics-Informed Neural Networks (PINNs) for Tumor Cell Growth Modeling. Mathematics 2024, 12, 1195.
Abstract
This paper presents a comprehensive investigation into the applicability and performance of two prominent growth models, namely the Verhulst model and the Montroll model, in the context of modeling tumor cell growth dynamics. Leveraging the power of Physics-Informed Neural Networks (PINNs), we aim to assess and compare the predictive capabilities of these models against experimental data obtained from the growth patterns of tumor cells. We employ a dataset comprising detailed measurements of tumor cell growth to train and evaluate the Verhulst and Montroll models. By integrating PINNs, we not only account for experimental noise but also embed physical insights into the learning process, enabling the models to capture the underlying mechanisms governing tumor cell growth. Our findings reveal the strengths and limitations of each growth model in accurately representing tumor cell proliferation dynamics. Furthermore, the study sheds light on the impact of incorporating physics-informed constraints on the model predictions. The insights gained from this comparative analysis contribute to advancing our understanding of growth models and their applications in predicting complex biological phenomena, particularly in the realm of tumor cell proliferation.
Keywords
physics-informed neural networks (PINNs); differential equation; loss function; activation function; deep learning; cancer cells; Montroll growth model; Verhulst growth model
Subject
Computer Science and Mathematics, Mathematical and Computational Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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